Bioinformatics
The bioinformatics group is an integrated unit and provides the necessary infrastructure for the scientists at BNITM for evaluation of data from high-throughput sequencing data. The technique has become an integral part of the methods applied in many research projects at BNITM. The primary role of the group is to offer tailored project support based of the specific needs of the scientists. Therefore, the group actively supports planning and implementation of sequencing analyses.
The main focus lies on the analysis of whole genome, metagenome and transcriptome sequencing according to the scientific needs of the working groups. Existing software is implemented and used in standard and automated bioinformatic workflows for structured transparent results. The support covers a broad spectrum of bioinformatics methods and offers project-specific analyses in addition to standardised quality controls. The analyses include genome assemblies, annotations, generation of phylogenies, comparative expression analyses, pan-genome screens, microbiome investigations and more. The department have access to a high-performance computer with 128 cores and 1 TB of RAM.
The method portfolio comprises standardised workflows and pipelines for various NGS applications:
Eukaryotes
- Exome analyses
- Transcriptome analyses
- Genome-wide association studies (GWAS)
- Identification of genetic variants
Bacteria
- Genome assemblies and functional annotations
- Pan-genome investigations
- Phylogenetic studies (MLST / cgMLST )
- Metagenome / microbiome analyses
- Transcriptome analyses
- Bacterial GWAS
- Screens for antimicrobial resistance genes
Viruses
- Genome assemblies and functional annotations
- Phylogenetic studies
- SARS Cov 2 analyses
Contact
- Dr Thorsten Thye
- Bioinformatics
- phone: +49 40 285380-403
- email: thye@bnitm.de
- Dr Stephan Lorenzen
- Bioinformatics
- phone: +49 40 285380-441
- email: lorenzen@bnitm.de
