Our publications

• 2023

  • Interaction of Mesonivirus and Negevirus with arboviruses and the RNAi response in Culex tarsalis-derived cells

    • Agboli E, Schulze J, Jansen S, Cadar D, Sreenu VB, Leggewie M, Altinli M, Badusche M, Jöst H, Börstler J, Schmidt-Chanasit J, Schnettler E
    • Parasit Vectors. 2023 Oct 13;16(1):361. doi: 10.1186/s13071-023-05985-w
    • 2023-10-13

  • The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses

    • Leggewie M, Scherer C, Altinli M, Gestuveo RJ, Sreenu VB, Fuss J, Vazeille M, Mousson L, Badusche M, Kohl A, Failloux AB, Schnettler E
    • PLoS Negl Trop Dis. 2023 Jul 13;17(7):e0011456. doi: 10.1371/journal.pntd.0011456
    • 2023-07-13

  • Agua Salud Alphavirus Infection, Dissemination and Transmission in Aedes aegypti Mosquitoes

    • Jagtap SV, Brink J, Frank SC, Badusche M, Leggewie M, Sreenu VB, Fuss J, Schnettler E, Altinli M
    • Viruses. 2023 May 3;15(5):1113. doi: 10.3390/v15051113
    • 2023-05-03

  • Antiviral RNAi Response in Culex quinquefasciatus-Derived HSU Cells

    • Altinli M, Leggewie M, Schulze J, Gyanwali R, Badusche M, Sreenu VB, Fuss J, Schnettler E
    • Viruses. 2023 Feb 4;15(2):436. doi: 10.3390/v15020436
    • 2023-02-04

• 2022

  • Antiviral RNAi Response against the Insect-Specific Agua Salud Alphavirus

    • Altinli M, Leggewie M, Badusche M, Gyanwali R, Scherer C, Schulze J, Sreenu VB, Fegebank M, Zibrat B, Fuss J, Junglen S, Schnettler E
    • mSphere. 2022 Feb 23;7(1):e0100321. doi: 10.1128/msphere.01003-21
    • 2022-02-23

  • Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs

    • Gestuveo RJ, Parry R, Dickson LB, Lequime S, Sreenu VB, Arnold MJ, Khromykh AA, Schnettler E, Lambrechts L, Varjak M, Kohl A
    • PLoS Pathog. 2022 Jan 6;18(1):e1010202. doi: 10.1371/journal.ppat.1010202
    • 2022-01-06

• 2021

  • Symbiotic Interactions Between Mosquitoes and Mosquito Viruses

    • Altinli M, Schnettler E, Sicard M
    • Front Cell Infect Microbiol. 2021 Aug 30;11:694020. doi: 10.3389/fcimb.2021.694020
    • 2021-08-30

  • An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

    • Scherer C, Knowles J, Sreenu VB, Fredericks AC, Fuss J, Maringer K, Fernandez-Sesma A, Merits A, Varjak M, Kohl A, Schnettler E
    • Viruses. 2021 Jun 3;13(6):1066. doi: 10.3390/v13061066
    • 2021-06-03

• 2020

  • aBravo Is a Novel Aedes aegypti Antiviral Protein that Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2

    • Varjak M, Gestuveo RJ, Burchmore R, Schnettler E, Kohl A
    • Viruses. 2020 Jul 11;12(7):748. doi: 10.3390/v12070748
    • 2020-07-11

  • Identification and RNAi Profile of a Novel Iflavirus Infecting Senegalese Aedes vexans arabiensis Mosquitoes

    • Parry R, Naccache F, Ndiaye EH, Fall G, Castelli I, Lühken R, Medlock J, Cull B, Hesson JC, Montarsi F, Failloux AB, Kohl A, Schnettler E, Diallo M, Asgari S, Dietrich I, Becker SC
    • Viruses. 2020 Apr 14;12(4):440. doi: 10.3390/v12040440
    • 2020-04-14

  • The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression

    • McFarlane M, Almire F, Kean J, Donald CL, McDonald A, Wee B, Lauréti M, Varjak M, Terry S, Vazeille M, Gestuveo RJ, Dietrich I, Loney C, Failloux AB, Schnettler E, Pondeville E, Kohl A
    • mSphere. 2020 Apr 8;5(2):e00081-20. doi: 10.1128/mSphere.00081-20
    • 2020-04-08

• 2019

  • Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin

    • Selinger M, Tykalová H, Štěrba J, Věchtová P, Vavrušková Z, Lieskovská J, Kohl A, Schnettler E, Grubhoffer L
    • PLoS Negl Trop Dis. 2019 Sep 27;13(9):e0007745. doi: 10.1371/journal.pntd.0007745
    • 2019-09-27

  • Mosquito-Specific Viruses-Transmission and Interaction

    • Agboli E, Leggewie M, Altinli M, Schnettler E
    • Viruses. 2019 Sep 17;11(9):873. doi: 10.3390/v11090873
    • 2019-09-17

  • Metaviromics Reveals Unknown Viral Diversity in the Biting Midge Culicoides impunctatus

    • Modha S, Hughes J, Bianco G, Ferguson HM, Helm B, Tong L, Wilkie GS, Kohl A, Schnettler E
    • Viruses. 2019 Sep 17;11(9):865. doi: 10.3390/v11090865
    • 2019-09-17

• 2018

  • Antiviral RNA Interference Activity in Cells of the Predatory Mosquito, Toxorhynchites amboinensis

    • Donald CL, Varjak M, Aguiar ERGR, Marques JT, Sreenu VB, Schnettler E, Kohl A
    • Viruses. 2018 Dec 6;10(12):694. doi: 10.3390/v10120694
    • 2018-12-06

  • RNAi-mediated antiviral immunity in insects and their possible application

    • Leggewie M, Schnettler E
    • Curr Opin Virol. 2018 Oct;32:108-114. doi: 10.1016/j.coviro.2018.10.004
    • 2018-11-12

  • Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells

    • Franzke K, Leggewie M, Sreenu VB, Jansen S, Heitmann A, Welch SR, Brennan B, Elliott RM, Tannich E, Becker SC, Schnettler E
    • J Gen Virol. 2018 Dec;99(12):1739-1745. doi: 10.1099/jgv.0.001173
    • 2018-11-05

  • The antiviral piRNA response in mosquitoes?

    • Varjak M, Leggewie M, Schnettler E
    • J Gen Virol. 2018 Dec;99(12):1551-1562. doi: 10.1099/jgv.0.001157
    • 2018-10-29

  • Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells

    • Varjak M, Dietrich I, Sreenu VB, Till BE, Merits A, Kohl A, Schnettler E
    • Viruses. 2018 Feb 18;10(2):88. doi: 10.3390/v10020088
    • 2018-02-18

• 2017

  • Characterization of the Zika virus induced small RNA response in Aedes aegypti cells

    • Varjak M, Donald CL, Mottram TJ, Sreenu VB, Merits A, Maringer K, Schnettler E, Kohl A
    • PLoS Negl Trop Dis. 2017 Oct 17;11(10):e0006010. doi: 10.1371/journal.pntd.0006010
    • 2017-10-17

  • Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection

    • Selinger M, Wilkie GS, Tong L, Gu Q, Schnettler E, Grubhoffer L, Kohl A
    • J Gen Virol. 2017 Aug;98(8):2043-2060. doi: 10.1099/jgv.0.000853
    • 2017-08-08

  • Understanding the role of microRNAs in the interaction of Aedes aegypti mosquitoes with an insect-specific flavivirus

    • Lee M, Etebari K, Hall-Mendelin S, van den Hurk AF, Hobson-Peters J, Vatipally S, Schnettler E, Hall R, Asgari S
    • J Gen Virol. 2017 Jul;98(7):1892-1903. doi: 10.1099/jgv.0.000832
    • 2017-07-12

  • RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems

    • Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux AB, Schnettler E, Kohl A, Becker SC
    • mSphere. 2017 May 3;2(3):e00090-17. doi: 10.1128/mSphere.00090-17
    • 2017-05-03

  • Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses

    • Varjak M, Maringer K, Watson M, Sreenu VB, Fredericks AC, Pondeville E, Donald CL, Sterk J, Kean J, Vazeille M, Failloux AB, Kohl A, Schnettler E
    • mSphere. 2017 May 3;2(3):e00144-17. doi: 10.1128/mSphere.00144-17
    • 2017-05-03

  • Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

    • Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S
    • Lancet Infect Dis.; 17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1
    • 2017-04-17

  • The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses

    • Dietrich I, Shi X, McFarlane M, Watson M, Blomström AL, Skelton JK, Kohl A, Elliott RM, Schnettler E
    • PLoS Negl Trop Dis. 2017 Jan 6;11(1):e0005272. doi: 10.1371/journal.pntd.0005272
    • 2017-01-06

• 2016

  • Wolbachia restricts insect-specific flavivirus infection in Aedes aegypti cells

    • Schnettler E, Sreenu VB, Mottram T, McFarlane M
    • J Gen Virol.;97(11):3024-3029. doi: 10.1099/jgv.0.000617
    • 2016-11-01

  • Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil

    • Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A
    • PLoS Negl Trop Dis.10(10):e0005048. doi: 10.1371/journal.pntd.0005048
    • 2016-10-05

  • The Importance of Socio-Economic Versus Environmental Risk Factors for Reported Dengue Cases in Java, Indonesia

    • Wijayanti SP, Porphyre T, Chase-Topping M, Rainey SM, McFarlane M, Schnettler E, Biek R, Kohl A
    • PLoS Negl Trop Dis. ;10(9):e0004964. doi: 10.1371/journal.pntd.0004964
    • 2016-09-07

  • Host inflammatory response to mosquito bites defines severity of arbovirus infection

    • Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS
    • Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002
    • 2016-06-21

  • Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways

    • Rainey SM, Martinez J, McFarlane M, Juneja P, Sarkies P, Lulla A, Schnettler E, Varjak M, Merits A, Miska EA, Jiggins FM, Kohl A
    • PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536
    • 2016-04-18

  • Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors

    • Wijayanti SP, Sunaryo S, Suprihatin S, McFarlane M, Rainey SM, Dietrich I, Schnettler E, Biek R, Kohl A
    • PLOS Neglected Tropical Diseases 2016 Mar 11;10(3):e0004500. doi: 10.1371/journal.pntd.0004500
    • 2016-03-11

  • Modulation of potassium channels inhibits bunyavirus infection

    • Hover S, King B, Hall B, Loundras EA, Taqi H, Daly J, Dallas M, Peers C, Schnettler E, McKimmie C, Kohl A, Barr JN, Mankouri J
    • J Biol Chem. 2016 Feb 12;291(7):3411-22. doi: 10.1074/jbc.M115.692673
    • 2016-02-12

  • Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements

    • Kohl A, Pondeville E, Schnettler E, Crisanti A, Supparo C, Christophides GK, Kersey PJ, Maslen GL, Takken W, Koenraadt CJ, Oliva CF, Busquets N, Abad FX, Failloux AB, Levashina EA, Wilson AJ, Veronesi E, Pichard M, Arnaud Marsh S, Simard F, Vernick KD
    • Pathogens and Global Health. 2016 Jun-Jul;110(4-5):164-72. doi: 10.1080/20477724.2016.1211475
    • 2016-01-01

• 2015

  • A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia

    • McLean BJ, Hobson-Peters J, Webb CE, Watterson D, Prow NA, Nguyen HD, Hall-Mendelin S, Warrilow D, Johansen CA, Jansen CC, van den Hurk AF, Beebe NW, Schnettler E, Barnard RT, Hall RA
    • Virology 2015 Dec;486:272-83. doi: 10.1016/j.virol.2015.07.021
    • 2015-12-01

  • Newly identified RNAs of Raspberry leaf blotch virus encoding a related group of proteins

    • Lu Y, McGavin W, Cock PJA, Schnettler E, Yan F, Chen J, MacFarlane S
    • Journal of General Virology. 2015 Nov;96(11):3432-3439. doi: 10.1099/jgv.0.000277
    • 2015-11-01

  • Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein

    • Blomström AL, Gu Q, Barry G, Wilkie G, Skelton JK, Baird M, McFarlane M, Schnettler E, Elliott RM, Palmarini M, Kohl A
    • BMC Genomics 2015 Apr 19;16:324. doi: 10.1186/s12864-015-1538-9
    • 2015-04-19

  • Fighting arbovirus transmission: nutural and engineerd control of vector competence in Aedes mosquitoes

    • Kean J, Rainey SM, McFarlane M, Donald CL, Schnettler E, Kohl A, Pondeville E
    • Insects. 2015 Mar 23;6(1):236-78. doi: 10.3390/insects6010236
    • 2015-03-23

• 2014

  • Induction and suppression of tick cell antiviral RNAi response by tick-borne flaviviruses

    • Schnettler E, Tykalová H, Watson M, Sharma M, Sterken MG, Obbard DJ, Lewis SH, McFarlane M, Bell-Sakyi L, Barry G, Weisheit S, Best SM, Kuhn RJ, Pijlman GP, Chase-Topping ME, Gould EA, Grubhoffer L, Fazakerley JK, Kohl A
    • Nucleic Acid Research. 2014 Aug;42(14):9436-46. doi: 10.1093/nar/gku657
    • 2014-01-01

  • Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication

    • McFarlane M, Arias-Goeta C, Martin E, O'Hara Z, Lulla A, Mousson L, Rainey SM, Misbah S, Schnettler E, Donald CL, Merits A, Kohl A, Failloux AB
    • PLOS neglected tropical diseases 8(7): e2994. doi: 10.1371/journal.pntd.0002994
    • 2014-01-01

  • NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

    • Barry G, Varela M, Ratinier M, Blomström AL, Caporale M, Seehusen F, Hahn K, Schnettler E, Baumgärtner W, Kohl A, Palmarini M
    • J Gen Virol. 2014 Aug;95(Pt 8):1640-1646. doi: 10.1099/vir.0.065425-0
    • 2014-01-01

• 2013

  • Gene silencing in tick cell lines using small interfering or long double-stranded RNA

    • Barry G, Alberdi P, Schnettler E, Weisheit S, Kohl A, Fazakerley JK, Bell-Sakyi L
    • Experimental and Applied Acarology. 2013 Mar;59(3):319-38. doi: 10.1007/s10493-012-9598-x
    • 2013-03-01

  • Non-structural proteins of arthropod-borne bunyaviruses: roles and functions

    • Eifan S, Schnettler E, Dietrich I, Kohl A, Blomström AL
    • Viruses. 2013 Oct 4;5(10):2447-68. doi: 10.3390/v5102447
    • 2013-01-01

  • viRome: an R package for the visualization and analysis of viral small RNA sequence datasets

    • Watson M, Schnettler E, Kohl A
    • Bioinformatics. 2013 Aug 1;29(15):1902-3. doi: 10.1093/bioinformatics/btt297
    • 2013-01-01

  • Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells.

    • Schnettler, E.#; Donald, C.L.; Human, S.; Watson, M.; Siu, R.W.C.; McFarlane, M.; Fazakerley, J.K.; Kohl, A. & Fragkoudis, R.# (2013)
    • J Gen Virol. 94 (7): 1680-1689
    • 2013-01-01

  • Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host

    • Varela M, Schnettler E, Caporale M, Murgia C, Barry G, McFarlane M, McGregor E, Piras IM, Shaw A, Lamm C, Janowicz A, Beer M, Glass M, Herder V, Hahn K, Baumgärtner W, Kohl A, Palmarini M
    • PLoS Pathog. 2013 Jan;9(1):e1003133. doi: 10.1371/journal.ppat.1003133
    • 2013-01-01

  • RNA interference targets arbovirus replication in Culicoides cells

    • Schnettler E, Ratinier M, Watson M, Shaw AE, McFarlane M, Varela M, Elliott RM, Palmarini M, Kohl A
    • J Virol. 2013 Mar;87(5):2441-54. doi: 10.1128/JVI.02848-12
    • 2013-01-01

• 2012

  • Prophenol oxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus

    • Rodriguez-Andres J, Rani S, Varjak M, Chase-Topping ME, Beck MH, Ferguson MC, Schnettler E, Fragkoudis R, Barry G, Merits A, Fazakerley JK, Strand MR, Kohl A
    • PLoS Pathog. 2012;8(11):e1002977. doi: 10.1371/journal.ppat.1002977
    • 2012-01-01

  • Non-coding flavivirus RNA displays RNAi suppressor activity in insect and mammalian cells

    • Schnettler E, Sterken MG, Leung JY, Metz SW, Geertsema C, Goldbach RW, Vlak JM, Kohl A, Khromykh AA, Pijlman GP
    • J Virol. 2012 Dec;86(24):13486-500. doi: 10.1128/JVI.01104-12
    • 2012-01-01

  • New insights into control of arbovirus replication and spread by insect RNA interference pathways

    • Donald CL, Kohl A, Schnettler E
    • Insects. 2012 May 29;3(2):511-31. doi: 10.3390/insects3020511
    • 2012-01-01

  • West Nile virus encodes a microRNA-like small RNA in the 3’ untranslated region which upregulates GATA4 mRNA and facilitates virus replication in mosquito cells

    • Hussain M, Torres S, Schnettler E, Funk A, Grundhoff A, Pijlman GP, Khromykh AA, Asgari S
    • Nucleic Acids Res. 2012 Mar;40(5):2210-23. doi: 10.1093/nar/gkr848
    • 2012-01-01

• 2011

  • Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules

    • Schnettler E, Hemmes H, Huismann R, Goldbach R, Prins M, Kormelink R
    • J Virol. 2010 Nov;84(21):11542-54. doi: 10.1128/JVI.00595-10
    • 2011-01-01

• 2010

  • Chikungunya virus nonstructural protein 2 inhibits type I/II interferon2 stimulated JAK-STAT signaling

    • Fros JJ, Liu WJ, Prow NA, Geertsema C, Ligtenberg M, Vanlandingham DL, Schnettler E, Vlak JM, Suhrbier A, Khromykh AA, Pijlman GP
    • J Virol. 2010 Oct;84(20):10877-87. doi: 10.1128/JVI.00949-10
    • 2010-01-01

• 2009

  • Binding of siRNA molecules is crucial for RNAi suppressor activity of Rice hoja blanca virus NS3 in plants

    • Hemmes H, Kaaij L, Lohuis D, Prins M, Goldbach R, Schnettler E
    • J Gen Virol. 2009 Jul;90(Pt 7):1762-1766. doi: 10.1099/vir.0.010488-0
    • 2009-01-01

  • The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat

    • Schnettler E, de Vries W, Hemmes H, Haasnoot J, Kormelink R, Goldbach R, Berkhout B
    • EMBO Rep. 2009 Mar;10(3):258-63. doi: 10.1038/embor.2009.6
    • 2009-01-01

• 2008

  • The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells

    • Schnettler E, Hemmes H, Goldbach R, Prins M
    • J Gen Virol. 2008 Jan;89(Pt 1):336-340. doi: 10.1099/vir.0.83293-0
    • 2008-01-01