Our Publications
2023
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells
- Sassmannshausen J, Bennink S, Distler U, Küchenhoff J, Minns AM, Lindner SE, Burda PC, Tenzer S, Gilberger TW, Pradel G
- Mol Microbiol. 2023 Jul 26. doi: 10.1111/mmi.15125
Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation
- Burda PC, Ramaprasad A, Bielfeld S, Pietsch E, Woitalla A, Söhnchen C, Singh MN, Strauss J, Sait A, Collinson LM, Schwudke D, Blackman MJ, Gilberger TW
- mBio. 2023 Jul 25:e0141323. doi: 10.1128/mbio.01413-23
The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake
- Alder A, Sanchez CP, Russell MRG, Collinson LM, Lanzer M, Blackman MJ, Gilberger TW, Matz JM
- Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2306420120. doi: 10.1073/pnas.2306420120
The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections
- Wichers-Misterek JS, Krumkamp R, Held J, von Thien H, Wittmann I, Höppner YD, Ruge JM, Moser K, Dara A, Strauss J, Esen M, Fendel R, Sulyok Z, Jeninga MD, Kremsner PG, Sim BKL, Hoffman SL, Duffy MF, Otto TD, Gilberger TW, Silva JC, Mordmüller B, Petter M, Bachmann A
- PLoS Pathog. 2023 Jun 29;19(6):e1011468. doi: 10.1371/journal.ppat.1011468
A malaria parasite phospholipase facilitates efficient asexual blood stage egress
- Ramaprasad A, Burda PC, Koussis K, Thomas JA, Pietsch E, Calvani E, Howell SA, MacRae JI, Snijders AP, Gilberger TW, Blackman MJ
- PLoS Pathog. 2023 Jun 23;19(6):e1011449. doi: 10.1371/journal.ppat.1011449
Variable microtubule architecture in the malaria parasite
- Ferreira JL, Pražák V, Vasishtan D, Siggel M, Hentzschel F, Binder AM, Pietsch E, Kosinski J, Frischknecht F, Gilberger TW, Grünewald K
- Nat Commun. 2023 Mar 3;14(1):1216. doi: 10.1038/s41467-023-36627-5
A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission
- Wichers-Misterek JS, Binder AM, Mesén-Ramírez P, Dorner LP, Safavi S, Fuchs G, Lenz TL, Bachmann A, Wilson D, Frischknecht F, Gilberger TW
- mBio. 2023 Feb 28;14(1):e0331822. doi: 10.1128/mbio.03318-22
2022
A choline- releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite
- Ramaprasad A, Burda PC, Calvani E, Sait AJ, Palma-Duran SA, Withers-Martinez C, Hackett F, Macrae J, Collinson L, Gilberger TW, Blackman MJ
- Elife. 2022 Dec 28;11:e82207. doi: 10.7554/eLife.82207
Characterisation of PfCZIF1 and PfCZIF2 in Plasmodium falciparum asexual stages
- Balbin JM, Heinemann GK, Yeoh LM, Gilberger TW, Armstrong M, Duffy MF, Gilson PR, Wilson DW
- Int J Parasitol. 2023 Jan;53(1):27-41. doi: 10.1016/j.ijpara.2022.09.008
Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation
- Alder A, Wilcke L, Pietsch E, von Thien H, Pazicky S, Löw C, Mesen-Ramirez P, Bachmann A, Burda PC, Kunick C, Sondermann H, Wilson D, Gilberger TW
- J Biol Chem. 2022 Sep;298(9):102360. doi: 10.1016/j.jbc.2022.102360
Analysis of var Gene Transcript Patterns by Quantitative Real-Time PCR
- Bachmann A, Lavstsen T
- Methods Mol Biol. 2022;2470:149-171. doi: 10.1007/978-1-0716-2189-9_13
PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development
- Wichers JS, Mesén-Ramírez P, Fuchs G, Yu-Strzelczyk J, Stäcker J, von Thien H, Alder A, Henshall I, Liffner B, Nagel G, Löw C, Wilson D, Spielmann T, Gao S, Gilberger TW, Bachmann A, Strauss J
- mBio. 2022 Apr 26;13(2):e0062322. doi: 10.1128/mbio.00623-22
The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression
- Quinn JE, Jeninga MD, Limm K, Pareek K, Meißgeier T, Bachmann A, Duffy MF, Petter M
- Front Cell Dev Biol. 2022 Apr 12;10:816558. doi: 10.3389/fcell.2022.816558
Plasmodium's bottomless pit: properties and functions of the malaria parasite's digestive vacuole
- Matz JM
- Trends Parasitol. 2022 Jul;38(7):525-543. doi: 10.1016/j.pt.2022.02.010
N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparum
- Pazicky S, Alder A, Mertens H, Svergun DI, Gilberger T, Löw C
- Biochem J. 2022 Feb 11;479(3):337-356. doi: 10.1042/BCJ20210829
Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites
- Liffner B, Balbin JM, Gerald J. Shami GJ, Siddiqui G, Strauss J, Frölich S, Heinemann GK, May E, Alder A, Wichers JW, Creek DJ, Tilley L, Dixon MW, Gilberger TW, Wilson DW
- Commun Biol. 2022 Feb 9;5(1):121. doi: 10.1038/s42003-022-03020-9
2021
Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the Malaria Parasite Plasmodium falciparum
- Wichers JS, van Gelder C, Fuchs G, Ruge JM, Pietsch E, Ferreira JL, Safavi S, von Thien H, Burda PC, Mesén-Ramirez P, Spielmann T, Strauss J, Gilberger TW, Bachmann A
- mSphere. 2021 Dec 22;6(6):e0074321. doi: 10.1128/mSphere.00743-21
The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost
- Mesén-Ramírez P, Bergmann B, Elhabiri M, Zhu L, von Thien H, Castro-Peña C, Gilberger TW, Davioud-Charvet E, Bozdech Z, Bachmann A, Spielmann T
- Cell Host Microbe. 2021 Dec 8;29(12):1774-1787.e9. doi: 10.1016/j.chom.2021.11.002
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
- Boltryk SD, Passecker A, Alder A, Carrington E, van de Vegte-Bolmer M, van Gemert GJ, van der Starre A, Beck HP, Sauerwein RW, Kooij TWA, Brancucci NMB, Proellochs NI, Gilberger TW, Voss TS
- Nat Commun. 2021 Aug 10;12(1):4806. doi: 10.1038/s41467-021-24954-4
Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
- Lande D, Nasereddin A, Alder A, Gilberger T, Dzikowski R, Grünefeld J, Kunick C
- Molecules. 2021 Aug 5;26(16):4739. doi: 10.3390/molecules26164739
A non-reactive natural product precursor of the duocarmycin family has potent and selective and antimalarial activity
- Alder A, Struck, NS, Xiu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD
- Cell Chem Biol. 2022 May 19;29(5):840-853.e6. doi: 10.1016/j.chembiol.2021.10.005
Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum
- Wichers JS, Wunderlich J, Heincke D, Pazicky S, Strauss J, Schmitt M, Kimmel J, Wilcke L, Scharf S, von Thien H, Burda PC, Spielmann T, Löw C, Filarsky M, Bachmann A, Gilberger TW
- Cell Microbiol. 2021 Sep;23(9):e13341. doi: 10.1111/cmi.13341
The Ins and Outs of Plasmodium Rhoptries, Focusing on the Cytosolic Side
- Liffner B, Balbin JM, Wichers JS, Gilberger TW, Wilson DW
- Trends Parasitol. 2021 Jul;37(7):638-650. doi: 10.1016/j.pt.2021.03.006
Common virulence gene expression in adult first-time infected malaria patients and severe cases
- Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JAM, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, D Otto T, Lavstsen T, Gilberger TW, Duffy M, Bachmann A
- Elife. 2021 Apr 28;10:e69040. doi: 10.7554/eLife.69040
High Content Analysis of Macrophage-Targeting EhPIb-Compounds against Cutaneous and Visceral Leishmania Species
- Fehling H, Niss H, Bea A, Kottmayr N, Brinker C, Hoenow S, Sellau J, Gilberger TW, Ting F, Landschulze D, Meier C, Clos J, Lotter H
- Microorganisms. 2021 Feb 18;9(2):422. doi: 10.3390/microorganisms9020422
The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite
- Ferreira JL, Heincke D, Wichers JS, Liffner B, Wilson DW, Gilberger TW
- Front Cell Infect Microbiol. 2021 Jan 8;10:611801. doi: 10.3389/fcimb.2020.611801
2020
The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins
- Bisio H, Chaabene RB, Sabitzki R, Maco B, Marq JB, Gilberger TW, Spielmann T, Soldati-Favre D
- mBio. 2020 Oct 20;11(5):e02092-20. doi: 10.1128/mBio.02092-20
Structural role of essential light chains in the apicomplexan glideosome
- Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C
- Commun Biol. 2020 Oct 13;3(1):568. doi: 10.1038/s42003-020-01283-8
Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum
- Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW
- Cell Rep. 2020 Jun 23;31(12):107817. doi: 10.1016/j.celrep.2020.107817
4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents
- Schweda SI, Alder A, Gilberger T, Kunick C
- Molecules. 2020 Jul 13;25(14):3187. doi: 10.3390/molecules25143187
PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes
- Liffner B, Frölich S, Heinemann GK, Liu B, Ralph SA, Dixon MWA, Gilberger TW, Wilson DW
- Nat Commun. 2020 Mar 16;11(1):1411. doi: 10.1038/s41467-020-15127-w
Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
- Lubiana P, Bouws P, Roth LK, Dörpinghaus M, Rehn T, Brehmer J, Wichers JS, Bachmann A, Höhn K, Roeder T, Thye T, Gutsmann T, Burmester T, Bruchhaus I, Metwally NG
- Sci Rep. 2020 Mar 11;10(1):4548. doi: 10.1038/s41598-020-61388-2
Structural Insights Into PfARO and Characterization of its Interaction With PfAIP
- Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson DW, Filarsky M, Burda PC, Zhang K, Junop M, Gilberger TW
- J Mol Biol. 2020 Feb 14;432(4):878-896. doi: 10.1016/j.jmb.2019.12.024
Stringent Selection of Knobby Plasmodium falciparum-Infected Erythrocytes during Cytoadhesion at Febrile Temperature
- Dörpinghaus M, Fürstenwerth F, Roth LK, Bouws P, Rakotonirinalalao M, Jordan V, Sauer M, Rehn T, Pansegrau E, Höhn K, Mesén-Ramírez P, Bachmann A, Lorenzen S, Roeder T, Metwally NG, Bruchhaus I
- Microorganisms. 2020 Jan 25;8(2):174. doi: 10.3390/microorganisms8020174
![[Translate to English:] Logo CSSB](/fileadmin/media/Forschung/forschungsgruppen/Pathogen/Abteilung_Zellulaere_Parasitologie/Logo_CSSB.jpg "[Translate to English:] CSSB"){kind=logo}
