DFG verlängert Förderung für Forschungsgruppe „Geschlechtsspezifische Unterschiede in der Immunantwort“ 

Die Forschungseinheit „Geschlechtsspezifische Unterschiede in der Immunantwort“ wird von der Deutschen Forschungsgemeinschaft (DFG) für weitere vier Jahre mit fünf Millionen Euro gefördert. An dem seit 2021 geförderten Projekt (FOR 5068) sind die UKE-Bereiche Immunologie, Autoimmunerkrankungen, Kinderheilkunde, Infektiologie und Tumorforschung, das Bernhard-Nocht-Institut für Tropenmedizin (BNITM), das Universitätsklinikum Mannheim sowie neu das Forschungszentrum Borstel (FZB) mit insgesamt neun Projektgruppen beteiligt. Leiter:innen der Forschungseinheit sind Prof. Dr. Marcus Altfeld, Direktor des Instituts für Immunologie des UKE und des Leibniz Instituts für Virologie (LIV), und Prof. Dr. Hanna Lotter vom BNITM. Gemeinsam wollen die Wissenschaftler:innen herausfinden, welche Ursachen und Mechanismen hinter den unterschiedlichen Reaktionen des Immunsystems von Frauen und Männern stecken. Insbesondere untersuchen die Forschenden, wie Geschlechtshormone die Funktion von Immunzellen beeinflussen. Denn je besser verstanden wird, wie sich biologische geschlechtsspezifische Unterschiede auf die Symptome und den Verlauf von Krankheiten auswirken, desto besser kann dies bei der Behandlung berücksichtigt werden. 

Zum Hintergrund: UKE – Research Unit 5068

Annika Bea, Bernhard Nocht Institut for Tropical Medicine,

was awarded as best poster presentation award granted by Tropical Medicine

and Infectious Disease an open access journal by MDPI, in the 7th World

Congress on Leishmaniasis, WorldLeish7, with the abstract entitled:

"Influence of leishmania infection on the biology of host cells"

on August 6, 2022, Cartagena, Colombia.

Congratulations Annika!

01.07.2022

Of gender differences in the defence against infection and a truly neglected tropical disease

This year's doctoral prizes of the Association of Friends of the Tropical Institute Hamburg e.V. (VdF) go to Dr Marie Groneberg (Natural Sciences) and Dr Luzia Veletzky (Medicine). They are endowed with 1,000 euros each and honour particularly outstanding dissertations at the Bernhard Nocht Institute for Tropical Medicine.

Men fall ill differently, women too. Compared to women, men contract numerous viral, bacterial and parasitic infections much more frequently and severely. These include, for example, hepatitis B, covid-19, tuberculosis, Helicobacter and amoebic infections.

Prof. Hannelore Lotter's Molecular Infection Immunology group studies, among other things, gender-specific immune reactions in the formation and regeneration of amoebic liver abscesses. She had already shown that the sex hormone testosterone favours the development of liver abscesses.

Regulatory protein partly responsible for sex difference

Marie Groneberg and her colleagues followed up on these results. They analysed sex-specific differences in the acquired immune response in amoebic liver abscesses and carried out detailed molecular investigations of the immune response in the mouse model.

Among other things, they determined the occurrence and number of immune cells characterised in detail and the concentration of immunological messengers in the liver and blood of normal mice and mice with a targeted genetic defect.

They showed that in experimental amoeba infections in the liver, a specific immunoregulatory protein (HIF-1alpha) is partly responsible for the stronger immune response of the male mice. The protein is present in the liver cells of both sexes in response to amoebic infection, but influences the immune cell response of male and female animals to different degrees. Targeted knockdown of HIF-1alpha in the liver reduces the inflammation- and abscess-promoting immune response in male mice and leads to the abolition of the sex difference.

Congratulations Marie!

Hamburg, 14 December 2021 - Dr Julie Sellau, scientist in the Molecular Infection Immunology group at the Bernhard Nocht Institute for Tropical Medicine, today receives the Werner Otto Award, endowed with 8000€, for her outstanding contribution to knowledge on gender-specific immunology. Her award-winning work was published in the renowned journal Nature Communications in July 2020.

Research on gender differences in infectious immunology is in its infancy. While men are more susceptible to infectious diseases, women are more prone to chronic inflammation and autoimmune diseases. In order to create better treatment options, it is important to clarify the causes.

The Lotter working group, in which Ms Sellau has been a researcher for four and a half years, is dedicated to precisely this question: Using the amoebic liver abscess, they showed that the male sex hormone testosterone causes certain immune cells, which are actually supposed to protect against invading pathogens, to increase inflammatory reactions in the liver. These immune cells thus contribute significantly to tissue damage. The findings of Dr. Sellau and her colleagues open up new approaches for more targeted personalised medicine.

Congratulations Julie!