All publications

• 2024

  • Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria

    • Kelly A. Hagadorn; Mary E. Peterson; Hemanta Kole; Kazutoyo Miura; Peter D. Crompton; Christine S. Hopp
    • Immunity. Volume 57 (issue 8)
    • 2024-08-13

  • Antimicrobial activity of NK cells to Trypanosoma cruzi infected human primary Keratinocytes

    • Keshia Kroh, Jessica Barton, Helena Fehling, Hanna Lotter, Beate Volkmer, Rüdiger Greinert, Mouna Mhamdi-Ghodbani, Andrea Vanegas Ramirez, Thomas Jacobs & Rosa Isela Gálvez
    • PLOS Neglected Tropical Diseases 18(7): e0012255
    • 2024-07-22

• 2023

  • Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential

    • Hamley M, Leyk S, Casar C, Liebold I, Al Jawazneh A, Lanzloth C, Böttcher M, Haas H, Richardt U, V. Rothlin C, Jacobs T, Huber S, Adlung L, Pelczar P, Henao-Mejia J, Bosurgi L
    • Eur. J. Immunol. https://doi.org/10.1002/eji.202350434
    • 2023-11-16

  • Pathogenetic mechanisms and treatment targets in cerebral malaria

    • Hadjilaou A, Brandi J, Riehn M, Friese MA, Jacobs T
    • Nat Rev Neurol. 19(11):688-709. https://doi.org/10.1038/s41582-023-00881-4
    • 2023-10-19

  • Plasmodium falciparum infection reshapes the human microRNA profiles of red blood cells and their extracellular vesicles

    • Wu Y, Leyk S, Torabi H, Höhn K, Honecker B, Del Pilar Martinez Tauler M, Cadar D, Jacobs T, Bruchhaus I, Galal Metwally N
    • iScience. 26(7), 107119. https://doi.org/https://doi.org/10.1016/j.isci.2023.107119
    • 2023-07-21

  • Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease

    • Soprano LL, Ferrero MR, Jacobs T, Couto AS, Duschak VG
    • Front Cell Infect Microbiol. 13. https://doi.org/10.3389/fcimb.2023.1028496
    • 2023-05-15

  • OMIP-93: A 41-color high parameter panel to characterize various co-inhibitory molecules and their ligands in the lymphoid and myeloid compartment in mice

    • Brandi J, Wiethe C, Riehn M, Jacobs T
    • Cytometry Part A. 2023 Aug;103(8):624-630. doi: 10.1002/cyto.a.24740
    • 2023-05-04

  • Knowledge, attitudes, behaviors, and serological status related to Chagas disease among Latin American migrants in Germany: A cross-sectional study in six German cities

    • Wirth M, Gálvez RI, Jochum J, Strauss R, Kristensen K, Stich A, Stegemann M, Stahl P, Puchner KP, Strasen J, Parisi S, Braasch T, Bender M, Hörning A, Hanke M, Störk S, Jacobs T, Pritsch M, Zoller T
    • Front Cell Infect Microbiol. 2023 Jan 25;12:1047281. doi: 10.3389/fcimb.2022.1047281
    • 2023-01-25

• 2022

  • Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings

    • Boswell KL, Watkins TA, Cale EM, Samsel J, Andrews SF, Ambrozak DR, Driscoll JI, Messina MA, Narpala S, Hopp CS, Cagigi A, Casazza JP, Yamamoto T, Zhou T, Schief WR, Crompton PD, Ledgerwood JE, Connors M, Gama L, Kwong PD, McDermott A, Mascola JR, Koup RA
    • Front Immunol. 2022 Dec 13;13:1087018. doi: 10.3389/fimmu.2022.1087018
    • 2022-12-13

  • Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion

    • Patel PN, Dickey TH, Hopp CS, Diouf A, Tang WK, Long CA, Miura K, Crompton PD, Tolia NH
    • Nat Commun. 2022 Oct 6;13(1):5888. doi: 10.1038/s41467-022-33336-3
    • 2022-10-06

  • Assessment of Plasmodium falciparum Antigen-Specific B Cells

    • Hopp CS, Taylor JJ, Crompton PD
    • Methods Mol Biol. 2022;2470:689-713. doi: 10.1007/978-1-0716-2189-9_52
    • 2022-07-27

  • Increased expression of multiple co-inhibitory molecules on malaria-induced CD8+ T cells are associated with increased function instead of exhaustion

    • Brandi J, Riehn M, Hadjilaou A, Jacobs T
    • Front Immunol. 2022 Jul 7;13:878320. doi: 10.3389/fimmu.2022.878320
    • 2022-07-05

  • Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options

    • Arana Y, Gálvez RI, Jacobs T
    • Front Immunol. 2022 Jun 23;13:866120. doi: 10.3389/fimmu.2022.866120
    • 2022-06-23

  • Exhausted PD-1+ TOX+ CD8+ T Cells Arise Only in Long-Term Experimental Trypanosoma cruzi Infection

    • Gálvez RI, Jacobs T
    • Front. Immunol. 2022 Jun 3;13:866179. doi: 10.3389/fimmu.2022.866179
    • 2022-06-08

  • Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support

    • Hopp CS, Skinner J, Anzick SL, Tipton CM, Peterson ME, Li S, Doumbo S, Kayentao K, Ongoiba A, Martens C, Traore B, Crompton PD
    • Sci Immunol. 2022 May 13;7(71):eabn1250. doi: 10.1126/sciimmunol.abn1250
    • 2022-05-13

• 2021

  • Deciphering the Plasmodium falciparum malaria-specific CD4+ T-cell response: ex vivo detection of high frequencies of PD-1+TIGIT+ EXP1-specific CD4+ T cells using a novel HLA-DR11-restricted MHC class II tetramer

    • Schulte S, Heide J, Ackermann C, Peine S, Ramharter M, Mackroth MS, Woost R, Jacobs T, Schulze zur Wiesch J
    • Clinical and Experimental Immunology. 2022 Apr 4;207(2):227-236. doi: 10.1093/cei/uxab027
    • 2021-12-08

  • The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors

    • Kuhne LA, Ksiezarczyk AM, Braumann KM, Reer R, Jacobs T, Röder B, Hötting K
    • Front Aging Neurosci. 2021 Nov 8;13:750401. doi: 10.3389/fnagi.2021.750401
    • 2021-11-08

  • Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma

    • Raacke M, Kerr A, Dörpinghaus M, Brehmer J, Wu Y, Lorenzen S, Fink C, Jacobs T, Roeder T, Sellau J, Bachmann A, Metwally NG, Bruchhaus I
    • Cells. 2021 Jul 1;10(7):1656. doi: 10.3390/cells10071656
    • 2021-07-01

  • Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species-specific barrier

    • Hopp CS, Kanatani S, Archer NK, Miller RJ, Liu H, Chiou KK, Miller LS, Sinnis P
    • EMBO Mol Med. 2021 Apr 9;13(4):e11796. doi: 10.15252/emmm.201911796
    • 2021-04-09

  • Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

    • Hopp CS, Sekar P, Diouf A, Miura K, Boswell K, Skinner J, Tipton CM, Peterson ME, Chambers MJ, Andrews S, Lu J, Tan J, Li S, Doumbo S, Kayentao K, Ongoiba A, Traore B, Portugal S, Sun PD, Long C, Koup RA, Long EO, McDermott AB, Crompton PD
    • J Exp Med. 2021 Apr 5;218(4):e20200901. doi: 10.1084/jem.20200901
    • 2021-04-05

• 2020

  • T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice

    • Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M
    • Eur J Immunol. 2021 Nov 9. doi: 10.1002/eji.202149424
    • 2020-11-09

  • Classification of invasive bloodstream infections and Plasmodium falciparum malaria using autoantibodies as biomarkers

    • Krumkamp R, Sunaina Struck N, Lorenz E, Zimmermann M, Gyau Boahen K, Sarpong N, Owusu-Dabo E, Pak GD, Jeon HJ, Marks F, Jacobs T, May J, Eibach D
    • Sci Rep 10, 21168 (2020). https://doi.org/10.1038/s41598-020-78155-y
    • 2020-11-01

  • Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

    • Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, Niangaly M, Cisse H, Doumtabe D, Skinner J, Sturdevant D, Ricklefs S, Virtaneva K, Asghar M, Homann MV, Turner L, Martins J, Allman EL, N'Dri ME, Winkler V, Llinás M, Lavazec C, Martens C, Färnert A, Kayentao K, Ongoiba A, Lavstsen T, Osório NS, Otto TD, Recker M, Traore B, Crompton PD, Portugal S
    • Nat Med. 2020 Dec;26(12):1929-1940. doi: 10.1038/s41591-020-1084-0
    • 2020-10-26

  • Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis

    • de Freitas e Silva R, Gálvez RI, Alves Pereira VR, Felinto de Brito ME, Choy SL, Lotter H, Bosurgi Lidia, Jacobs T
    • Front. Immunol., 22 October 2020 doi.org/10.3389/fimmu.2020.574491
    • 2020-10-22

  • Analysis of Co-Inhibitory Receptor Expression in COVID-19 Infection Compared to Acute Plasmodium Falciparum Malaria: LAG-3 and TIM-3 Correlate with T Cell Activation and Course of Disease

    • Herrmann M, Schulte S, Wildner NH, Wittner M, Brehm TT, Ramharter M, Woost R, Lohse A, Jacobs T, Schulze Zur Wiesch J
    • Front. Immunol., 26 August 2020 doi:10.3389/fimmu.2020.01870
    • 2020-08-26

  • Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1

    • Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H
    • Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y
    • 2020-07-10

  • Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria

    • Heide J, Wildner N, Ackermann C, Wittner M, Marget M, Sette A, Sidney J, Jacobs T, Schulze Zur Wiesch J
    • Front. Immunol. 2020 Jan 22 doi:10.3389/fimmu.2019.03037
    • 2020-01-22

• 2019

  • Determinants of Post-Malarial Anemia in African Children Treated With Parenteral Artesunate

    • Scheu K, Adegnika AA, Addo MM, Ansong D, Cramer JP, Fürst S, Kremsner PG, Kurth F, Jacobs T, May J, Ramharter M, Sylverken J, Vinnemeier CD, Agbenyega T, Rolling T
    • Sci Rep. 2019 Dec 21; doi: 10.1038/s41598-019-54639-4
    • 2019-12-21

  • Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

    • Kaminski LC, Riehn M, Abel A, Steeg C, Dekugmen Yar D, Addai-Mensah O, Aminkiah F, Owusu-Dabo E, Jacobs T, Mackroth MS
    • Front. Immunol., 2019 Dec 11 doi:10.3389/fimmu.2019.02917
    • 2019-12-11

  • Atypical Memory B-cells Are Associated With Plasmodium falciparum Anemia Through Anti-Phosphatidylserine Antibodies

    • Rivera-Correa J, Mackroth MS, Jacobs T, Schulze Zur Wiesch J, Rolling T, Rodriguez A
    • Elife. 2019 Nov 12; doi: 10.7554/eLife.48309
    • 2019-11-12

  • Cytokine Profile Distinguishes Children With P. Falciparum Malaria From Those With Bacterial Blood Stream Infections

    • Struck NS, Zimmermann M, Krumkamp R, Lorenz E, Jacobs T, Rieger T, Wurr S, Günther S, Gyau Boahen K, Marks F, Sarpong N, Owusu-Dabo E, May J, Eibach D
    • J Infect Dis. 2019 Nov 8; doi: 10.1093/infdis/jiz587
    • 2019-11-08

  • HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules

    • Ackermann C, Smits M, Woost R, Eberhard JM, Peine S, Kummer S, Marget M, Kuntzen T, Kwok WW, Lohse AW, Jacobs T, Boettler T, Schulze Zur Wiesch J
    • Sci Rep. 2019 Jul 23;9(1):10624. doi: 10.1038/s41598-019-47024-8
    • 2019-07-23

  • Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes

    • Heide J, Vaughan KC, Sette A, Jacobs T, Schulze Zur Wiesch J
    • Front Immunol. 2019 Mar 21;10:397. doi: 10.3389/fimmu.2019.00397
    • 2019-03-21

  • Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria

    • Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS
    • Sci Rep. 2018 Mar 19;8(1):4789. doi: 10.1038/s41598-018-22659-1
    • 2019-03-19

• 2018

  • HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage

    • Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T
    • Front Immunol. 2018 Nov 13;9:2611. doi: 10.3389/fimmu.2018.02611
    • 2018-11-13

  • Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

    • Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca E, Gagliani N, Huber S
    • Nat Commun. 2018; 9:5457. doi: 10.1038/s41467-018-07581-4
    • 2018-09-01

  • Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo

    • Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ
    • Sci Rep. 2018 Jan 9;8(1):154. doi: 10.1038/s41598-017-18283-0
    • 2018-01-09

• 2017

  • Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

    • Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P
    • PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586
    • 2017-09-18

• 2016

  • Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection

    • Theeß W, Sellau J, Steeg C, Klinke A, Baldus S, Cramer JP, Jacobs T
    • Infect Immun. 2016 Dec 29;85(1). pii: e00475-16. doi: 10.1128/IAI.00475-16
    • 2016-12-29

  • Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function

    • Mackroth MS, Abel A, Steeg C, Schulze Zur Wiesch J, Jacobs T
    • PLoS Pathog. 2016 Nov 1;12(11):e1005909. doi: 10.1371/journal.ppat.1005909
    • 2016-11-01

  • IL-22 dampens the T cell response in experimental malaria

    • Sellau J, Alvarado CF, Hoenow S, Mackroth MS, Kleinschmidt D, Huber S, Jacobs T
    • Sci. Rep. (2016) 6, 28058; doi: 10.1038/srep28058
    • 2016-06-01

  • Palmitoyl transferases have critical roles in the development of mosquito and liver stages of Plasmodium

    • Hopp CS, Balaban AE, Bushell ES, Billker O, Rayner JC, Sinnis P
    • Cell Microbiol. 2016 Nov;18(11):1625-1641. doi: 10.1111/cmi.12601
    • 2016-04-16

  • IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage

    • Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
    • J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013
    • 2016-01-22

  • Unique human immune signature of Ebola virus disease in Guinea

    • Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Christopher H. Logue, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Fabrizio Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet F, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S & Muñoz-Fontela C
    • Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949
    • 2016-01-01

• 2015

  • EBI3 suppresses Th1, Th17 and Th2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation

    • Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H
    • Immunology. 2015 Dec 23. doi: 10.1111/imm.12565
    • 2015-12-23

  • Mycobacterium tuberculosis Coinfection Has No Impact on Plasmodium berghei ANKA-Induced Experimental Cerebral Malaria in C57BL/6 Mice

    • Blank J, Behrends J, Jacobs T, Schneider BE
    • Infect Immun. 2015 Dec 7;84(2):502-10. doi: 10.1128/IAI.01290-15
    • 2015-12-07

  • The Application of Anti-Toso Antibody Enhances CD8+ T Cell Responses in Experimental Malaria Vaccination and Disease

    • Lapke N, Tartz S, Lee KH, Jacobs T
    • Vaccine. 2015 Nov 27;33(48):6763-70. doi: 10.1016/j.vaccine.2015.10.065
    • 2015-12-01

  • Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

    • Hopp CS, Chiou K, Ragheb DR, Salman AM, Khan SM, Liu AJ, Sinnis P
    • Elife. 2015 Aug 13;4:e07789. doi: 10.7554/eLife.07789
    • 2015-08-13

  • Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E

    • Ferrero MR, Heins AM, Soprano LL, Acosta DM, Esteva MI, Jacobs T*, Duschak VG* *shared senior authors
    • Med Microbiol Immunol. 2016 Feb;205(1):21-35. doi: 10.1007/s00430-015-0421-2
    • 2015-06-06

  • The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin

    • Hopp CS, Sinnis P
    • Ann N Y Acad Sci. 2015 Apr;1342(1):37-43. doi: 10.1111/nyas.12661
    • 2015-02-18

  • Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection

    • Breloer M, Hartmann W, Blankenhaus B, Eschbach ML, Pfeffer K, Jacobs T
    • J Immunol. 2015 Feb 15;194(4):1413-6. doi: 10.4049/jimmunol.1402510
    • 2015-02-15

• 2014

  • Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory

    • Espinoza Mora R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B & Jacobs T
    • PLoS One. 2014 Aug 12;9(8):e104627. doi: 10.1371/journal.pone.0104627
    • 2014-12-01

  • Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex

    • Bernin H, Marggraff C, Jacobs T, Brattig N, An L, Blessmann J, Lotter H
    • BMC Infect Dis. 2014 Nov 25;14:621. doi: 10.1186/s12879-014-0621-1
    • 2014-11-25

• 2013

  • Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells

    • Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
    • J Immunol. 2013 Dec 1;191(11):5574-82. doi: 10.4049/jimmunol.1300826
    • 2013-12-01

  • Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells

    • Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E
    • PLoS One. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694
    • 2013-08-01

  • A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine

    • Nagel A, Prado M, Heitmann A, Tartz S, Jacobs T, Deschermeier C, Helm S, Stanway R, Heussler V
    • Int J Parasitol. 2013 May;43(6):503-14. doi: 10.1016/j.ijpara.2013.01.010
    • 2013-05-01

  • Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells

    • Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T
    • Eur J Immunol. 2013 Mar;43(3):693-704. doi: 10.1002/eji.201142262
    • 2013-03-01

  • TNFα-mediated liver destruction by kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection

    • Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H
    • PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096
    • 2013-01-09

• 2012

  • Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase

    • Hopp CS, Flueck C, Solyakov L, Tobin A, Baker DA
    • PLoS One. 2012;7(11):e48206. doi: 10.1371/journal.pone.0048206
    • 2012-11-05

  • Dissection of minimal sequence requirements for rhoptry membrane targeting in the malaria parasite

    • Cabrera A, Herrmann S, Warszta D, Santos JM, John Peter AT, Kono M, Debrouver S, Jacobs T, Spielmann T, Ungermann C, Soldati-Favre D, Gilberger TW
    • Traffic. 2012 Oct;13(10):1335-50. doi: 10.1111/j.1600-0854.2012.01394.x
    • 2012-10-13

  • Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection

    • Kolbaum J, Eschbach ML, Steeg C, Jacobs T, Fleischer B, Breloer M
    • Parasite Immunol. 2012 Jul;34(7):388-93. doi: 10.1111/j.1365-3024.2012.01369.x
    • 2012-07-01

  • Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

    • Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T*, Breloer M* *contributed equally
    • Eur J Immunol. 2012 Apr;42(4):890-900. doi: 10.1002/eji.201141955
    • 2012-04-01

• 2011

  • B and T Lymphocyte Attenuator (BTLA) Restricts the Protective Immune Response Against Experimental Malaria

    • Adler G, Steeg C, Pfeffer K, Murphy TL, Murphy KM, Langhorne J, Jacobs T
    • J Immunol. 2011 Nov 15;187(10):5310-9. doi: 10.4049/jimmunol.1101456
    • 2011-11-15

  • Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice

    • Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kühl AA, Loddenkemper C, Jacobs T, Breloer M
    • J Immunol. 2011 Apr 1;186(7):4295-305. doi: 10.4049/jimmunol.1001920
    • 2011-04-01

  • Invasion of Trypanosoma cruzi into host cells is impaired by N-propionylmannosamine and other N-acylmannosamines

    • Lieke T, Gröbe, Blanchard V, Grunow D, Tauber R, Zimmermann-Kordmann M, Jacobs T, Reutter W
    • Glycoconj J. 2011 Jan;28(1):31-7. doi: 10.1007/s10719-010-9321-2
    • 2011-01-28

• 2010

  • Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP1

    • Weiss R, Gabler M, Jacobs T, Gilberger TW, Thalhamer J, Scheiblhofer S
    • Vaccine. 2010 Jun 17;28(28):4515-22. doi: 10.1016/j.vaccine.2010.04.054
    • 2010-06-17

  • Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi

    • Jacobs T, Erdmann H, Fleischer B
    • Eur J Cell Biol. 2010 Jan;89(1):113-6. doi: 10.1016/j.ejcb.2009.10.006
    • 2010-01-01

• 2009

  • Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria

    • Steeg C, Adler A, Sparwasser T, Fleischer B, Jacobs T
    • J Immunol. 2009 Dec 1;183(11):7014-22. doi: 10.4049/jimmunol.0901422
    • 2009-12-01

  • Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E)

    • Erdmann H, Steeg C, Koch-Nolte F, Fleischer B, Jacobs T
    • Cell Microbiol. 2009 Nov;11(11):1600-11. doi: 10.1111/j.1462-5822.2009.01350.x
    • 2009-11-11

  • Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess

    • Lotter H, González-Roldán N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer AJ, Holst O, Tannich E, Jacobs T
    • PLoS Pathog. 2009 May;5(5):e1000434. doi: 10.1371/journal.ppat.1000434
    • 2009-05-05

• 2008

  • Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

    • Tartz S, Rüssmann H, Kamanova J, Sebo P, Sturm A, Heussler V, Fleischer B, Jacobs T
    • Vaccine. 2008 Nov 5;26(47):5935-43. doi: 10.1016/j.vaccine.2008.08.057
    • 2008-11-05

  • MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection

    • Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Liu X, Seeberger PH, Jacobs T
    • Microbes Infect. 2008 Oct;10(12-13):1259-65. doi: 10.1016/j.micinf.2008.07.024
    • 2008-10-10

  • Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help

    • Grenningloh R, Darji A, Bauer H., zur Lage S, Chakraborty T, Jacobs T, Weiss S
    • Scand J Immunol. 2008 Jun;67(6):594-602. doi: 10.1111/j.1365-3083.2008.02112.x
    • 2008-06-01

  • The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum

    • Gelhaus C, Jacobs T, Andrä J, Leippe M
    • Antimicrob Agents Chemother. 2008 May;52(5):1713-20. doi: 10.1128/AAC.01342-07
    • 2008-05-01

  • Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria

    • Kobbe R, Schreiber N, May J, Jacobs T
    • Antimicrob Agents Chemother. 2008 Apr;52(4):1583-4. doi: 10.1128/AAC.01428-07
    • 2008-04-01

  • Induction of experimental cerebral malaria is independent of TLR2/4/9

    • Lepenies B, Cramer JP, Burchard GD, Wagner H, Kirschning CJ, Jacobs T
    • Med Microbiol Immunol. 2008 Mar;197(1):39-44. doi: 10.1007/s00430-007-0057-y
    • 2008-03-01

• 2007

  • Ligation of B and T lymphocyte attenuator (BTLA) prevents the genesis of experimental cerebral malaria

    • Lepenies B, Pfeffer K, Hurchla MA, Murphy TL, Murphy KM, Oetzel J, Fleischer B, Jacobs T
    • J Immunol. 2007 Sep 15;179(6):4093-100. doi: 10.4049/jimmunol.179.6.4093
    • 2007-09-15

  • The cholesterol dependent cytolysin Listeriolysin O, aggregates rafts via oligomerization

    • Gekara NO, Jacobs T, Chakraborty T, Weiss S
    • Cell Microbiol. 2005 Sep;7(9):1345-56. doi: 10.1111/j.1462-5822.2005.00561.x
    • 2007-09-07

  • CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections

    • Lepenies B, Gaworski I, Tartz S, Langhorne J, Fleischer B, Jacobs T
    • Microbes Infect. 2007 May;9(6):687-94. doi: 10.1016/j.micinf.2007.02.013
    • 2007-05-01

• 2006

  • Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice

    • Reiling L*, Jacobs T*, Gaworski I, Kroemer K, Graefe G, Clos J *contributed equally
    • Infect Immun. 2006 Nov;74(11):6027-36.2006 Nov;74(11):6027-36. doi: 10.1128/IAI.00773-05
    • 2006-11-01

  • Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts

    • Lieke T, Steeg C, Graefe SE, Fleischer B, Jacobs T
    • Clin Exp Immunol. 2006 Aug;145(2):357-64. doi: 10.1111/j.1365-2249.2006.03118.x
    • 2006-08-01

  • Immunization with a circumsporozoite epitope fused to Bordetella adenylate cyclase in conjunction with CTLA-4 blockade confers protection against P. berghei liver stage malaria

    • Tartz S, Kamanova J, Simsova M, Sebo P, Bolte S, Heussler V, Fleischer B, Jacobs T
    • Infect Immun. 2006 Apr;74(4):2277-85. doi: 10.1128/IAI.74.4.2277-2285.2006
    • 2006-04-01

  • Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease

    • Lotter H*, Jacobs T*, Gaworski I, Tannich E. *contributed equally
    • Infect Immun. 2006 Jan;74(1):118-24. doi: 10.1128/IAI.74.1.118-124.2006
    • 2006-01-01

• 2005

  • Complement C3 is required for progression of cutaneous lesions and parasite dissemination in Leishmania major infection

    • Jacobs T, Andrä J, Gaworski I, Graefe S, Mellenthin K, Krömer M, Halter R, Borlak J, Clos J
    • Med Microbiol Immunol. 2005 May;194(3):143-9. doi: 10.1007/s00430-004-0229-y
    • 2005-05-01