Our research group focuses on understanding host-parasite interactions in Trypanosoma cruzi (T. cruzi), the parasite responsible for Chagas disease. We aim to identify potential therapeutic targets and improve treatment options for this neglected disease. Our research initially centered on the role of T cell regulation during T. cruzi infection, particularly the co-inhibitory molecules that influence CD8+ T cell responses. While blocking these molecules during the acute phase had no impact on parasite clearance, our studies revealed that during the chronic phase, the co-expression of specific markers such as TOX and PD-1 can significantly alter CD8+ T cell function, influencing both parasite control and inflammation.

In addition to studying T cell responses, we also focus on understanding how T. cruzi persists in muscle tissue, which is a key factor in the development of Chronic Chagas Cardiomyopathy (CCC). We have performed extensive studies using human muscle cell cultures and next-generation sequencing (NGS) to investigate how infection and pro-inflammatory cytokines affect these cells, as well as how T cells interact with infected muscle cells. These efforts are helping to uncover the molecular pathways involved in parasite persistence and inflammation.

Our lab is committed to advancing research on Chagas disease by developing novel therapeutic strategies and potential vaccines. We work in close collaboration with researchers internationally, especially in the USA and South America, to expand our understanding of T. cruzi infection and its impact on human health. For more information on our work, please publications page.