2024

Evaluation of knowledge, attitude and practice towards loiasis in the rural community of Sindara, in central African Gabon.

Hildebrandt TR, Davi SD, Kabwende AL, Endamne LR, Mehmel E, Rakotonirinalalao M, Alabi A, Manego RZ, Kremsner PG, Lell B, Adegnika AA, Mombo-Ngoma G, Mischlinger J, Agnandji ST, Ramharter M. PLoS Negl Trop Dis. 2024 May 23;18(5):e0012109. doi: 10.1371/journal.pntd.0012109. 2024-05-23

Eosinophils, basophils and myeloid-derived suppressor cells in chronic Loa loa infection and its treatment in an endemic setting.

Burger G, Adamou R, Kreuzmair R, Ndoumba WN, Mbassi DE, Mouima AMN, Tabopda CM, Adegnika RM, More A, Okwu DG, Mbadinga LD, Calle CL, Veletzky L, Metzger WG, Mordmüller B, Ramharter M, Mombo-Ngoma G, Adegnika AA, Zoleko-Manego R, McCall MBB. PLoS Negl Trop Dis. 2024 May 21;18(5):e0012203. doi: 10.1371/journal.pntd.0012203. 2024-03-21

Dynamics of Plasmodium species and genotype diversity in adults with asymptomatic infection in Gabon.

Inoue J, Galys A, Rodi M, Ekoka Mbassi D, Mombo-Ngoma G, Adegnika AA, Ramharter M, Zoleko-Manego R, Kremsner PG, Mordmüller B, Held J. Int J Infect Dis. 2024 Jun;143:107013. doi: 10.1016/j.ijid.2024.107013. 2024-03-16

Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections.

Veletzky L, Eberhardt KA, Hergeth J, Stelzl DR, Zoleko Manego R, Kreuzmair R, Burger G, Mischlinger J, McCall MBB, Mombo-Ngoma G, Adegnika AA, Agnandji ST, Matsiegui PB, Lell B, Kremsner P, Mordmüller B, Tappe D, Ramharter M. PLoS Negl Trop Dis. 2024 Mar 14;18(3):e0012054. doi: 10.1371/journal.pntd.0012054. 2024-03-14

Safety and efficacy of dihydroartemisinin–piperaquine for intermittent preventive treatment of malaria in pregnant women with HIV from Gabon and Mozambique: a randomised, double-blind, placebo-controlled trial

Raquel González, Tacilta Nhampossa, Ghyslain Mombo-Ngoma, Johannes Mischlinger, Meral Esen, André-Marie Tchouatieu, Anete Mendes, Antía Figueroa-Romero, Rella Zoleko-Manego, Bertrand Lell, Heimo Lagler, Linda Stoeger, Lia Betty Dimessa, Myriam El Gaaloul, Sergi Sanz, Susana Méndez, Mireia Piqueras, Esperança Sevene, Michael Ramharter, Francisco Saúte, Clara Menendez, Frédérique Mbang Abba, Marc Bañuls, Saskia Dede Davi, Wilfrid Ndzebe Ndoumba, Maura Mazuze, Ulysse Pascale Minkobame Zaga Minko, Clara Pons-Duran, Arnau Vañó-Boira, Teodora Vaz. The Lancet Infectious Diseases, Volume 24, Issue 5, 2024

2023

The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis.

Ramharter M, Butler J, Mombo-Ngoma G, Nordmann T, Davi SD, Zoleko Manego R. Lancet Infect Dis. 2023 Oct 16:S1473-3099(23)00438-3. doi: 10.1016/S1473-3099(23)00438-3. 2023-10-16

Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.

D Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R. EBioMedicine. 2023 Nov;97:104814. doi: 10.1016/j.ebiom.2023.104814. 2023-10-13.

Efficacy, safety, and tolerability of albendazole and ivermectin based regimens for the treatment of microfilaraemic loiasis in adult patients in Gabon: A randomized controlled assessor blinded clinical trial.

Zoleko-Manego R, Kreuzmair R, Veletzky L, Ndzebe-Ndoumba W, Ekoka Mbassi D, Okwu DG, Dimessa-Mbadinga-Weyat LB, Houtsa-Temgoua RD, Mischlinger J, McCall MBB, Kresmner PG, Agnandji ST, Lell B, Adegnika AA, Mombo-Ngoma G, Ramharter M. PLoS Negl Trop Dis. 2023 Aug 28;17(8):e0011584. doi: 10.1371/journal.pntd.0011584. 2023-08-28

Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.

Gansane A, Lingani M, Yeka A, Nahum A, Bouyou-Akotet M, Mombo-Ngoma G, Kaguthi G, Barceló C, Laurijssens B, Cantalloube C, Macintyre F, Djeriou E, Jessel A, Bejuit R, Demarest H, Marrast AC, Debe S, Tinto H, Kibuuka A, Nahum D, Mawili-Mboumba DP, Zoleko-Manego R, Mugenya I, Olewe F, Duparc S, Ogutu B. Malar J. 2023 Jan 3;22(1):2. doi: 10.1186/s12936-022-04420-2. 2023-01-03

2022

Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells. 

Dalimot JJ, Klei TRL, Beuger BM, Dikmen Z, Bouwman SAM, Mombo-Ngoma G, Zoleko-Manego R, Ndzebe-Ndoumba WF, Egée S, Kuijpers TW, Grobusch MP, van Bruggen R. Blood Adv. 2022 Nov 8;6(21):5798-5810. doi: 10.1182/bloodadvances.2021006171. 2022-11-08

Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study.

Zoleko-Manego R, Okwu DG, Handrich C, Dimessa-Mbadinga LB, Akinosho MA, Ndzebe-Ndoumba WF, Davi SD, Stelzl D, Veletzky L, Kreidenweiss A, Nordmann T, Adegnika AA, Lell B, Kremsner PG, Ramharter M, Mombo-Ngoma G. PLoS Negl Trop Dis. 2022 Oct 31;16(10):e0010899. doi: 10.1371/journal.pntd.0010899. 2022-10-31

Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon.

Veletzky L, Eberhardt KA, Hergeth J, Stelzl DR, Zoleko Manego R, Mombo-Ngoma G, Kreuzmair R, Burger G, Adegnika AA, Agnandji ST, Matsiegui PB, Boussinesq M, Mordmüller B, Ramharter M. PLoS Negl Trop Dis. 2022 Sep 19;16(9):e0010793. doi: 10.1371/journal.pntd.0010793. 2022-09-19

Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials.

Pons-Duran C, Mombo-Ngoma G, Macete E, Desai M, Kakolwa MA, Zoleko-Manego R, Ouédragou S, Briand V, Valá A, Kabanywanyi AM, Ouma P, Massougbodji A, Sevene E, Cot M, Aponte JJ, Mayor A, Slutsker L, Ramharter M, Menéndez C, González R. PLoS Med. 2022 Sep 2;19(9):e1004084. doi: 10.1371/journal.pmed.1004084. 2022-09-02

Performance of Field's Stain Compared with Conventional Giemsa Stain for the Rapid Detection of Blood Microfilariae in Gabon.

Mbassi FE, Mombo-Ngoma G, Ndoumba WN, Yovo EK, Eberhardt KA, Mbassi DE, Adegnika AA, Agnandji ST, Bouyou-Akotet MK, Ramharter M, Zoleko-Manego R. Am J Trop Med Hyg. 2022 Jul 5;107(2):383-7. doi: 10.4269/ajtmh.22-0061. 2022-07-05

2021

Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project).

González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C. BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197. 2021-11-23

Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma.

Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A. PLoS Negl Trop Dis. 2021 Jun 24;15(6):e0009511. doi: 10.1371/journal.pntd.0009511. 2021-06-24

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.

Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4. 2021-05-19

In vitro activity of eravacycline, a novel synthetic halogenated tetracycline, against the malaria parasite Plasmodium falciparum.

Koehne E, Kreidenweiss A, Adegbite BR, Manego RZ, McCall MBB, Mombo-Ngoma G, Adegnika AA, Agnandji ST, Mordmüller B, Held J. J Glob Antimicrob Resist. 2021 Mar; 24:93-97. doi: 10.1016/j.jgar.2020.11.024. 2021-03-24