Our publications

2024
- Cytoadhesion of Plasmodium falciparum-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells
  - Johannes Allweier, Michael Bartels, Hanifeh Torabi, Maria del Pilar Martinez Tauler, Nahla Galal Metwally, Thomas Roeder, Thomas Gutsmann, Iris Bruchhaus
  - Mol Microbiol. Online ahead of print.
  - 2024-12-04
- A system for functional studies of the major virulence factor of malaria parasites
  - Jakob Cronshagen, Johannes Allweier, Paolo Mesén-Ramírez, Jan Stäcker, Anna Viktoria Vaaben, Gala Ramón-Zamorano, Isabel Naranjo, Susann Ofori, Pascal WTC Jansen, Joëlle Hornebeck, Florian Kieferle, Agnes Murk, Elicia Martin, Carolina Castro-Peña, Richárd Bártfai, Thomas Lavstsen, Iris Bruchhaus, Tobias Spielmann
  - eLife, Reviewed Preprint
  - 2024-11-26
- Distinct brain and lung endothelial miRNA/mRNA profiles after exposure to Plasmodium falciparum-infected red blood cells
  - Nahla Galal Metwally*, Maria del Pilar Martinez Tauler*, Hanifeh Torabi*, Johannes Allweier*, Sara Mohamed, Maryeva Bessemoulin, Philip Bouws, Fatima Alshikh, Yifan Wu, Milad Temori, Tabea Schell, Maximillian Rakotonirinalalao, Barbara Honecker, Katharina Höhn, Thomas Jacobs, Holger Heine, Iris Bruchhaus
  - iScience. 2024 Oct 28;27(11):111265.
  - 2024-11-15
- FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells
  - Uliczka Karin, Bossen Judith, Zissler Ulrich M., Fink Christine, Niu Xiao, Pieper Mario, Prange Ruben D., Vock Christina, Wagner Christina, Knop Mirjam, Abdelsadik Ahmed, Franzenburg Sören, Bruchhaus Iris, Wegmann Michael, Schmidt-Weber Carsten B., König Peter, Pfefferle Petra, Heine Holger, Roeder Thomas
  - eLife 13:RP96385, reviewed preprint
  - 2024-04-19
2023
- Genes differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity-associated phenotypes by multiple mechanisms
  - Juliett Anders, Constantin König, Corinna Lender, Arne Hellhund, Sarah Nehls, Ibrahim Shalabi, Barbara Honecker, Stephan Lorenzen, Martin Meyer, Jenny Matthiesen, Dániel Cadar, Thomas Roeder, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus
  - PLoS Pathog. 2023 Dec 22;19(12):e1011745. doi: 10.1371/journal.ppat.1011745. PMID: 38134215; PMCID: PMC10773965.
  - 2023-12-26
- Plasmodium falciparum infection reshapes the human microRNA profiles of red blood cells and their extracellular vesicles
  - Yifan Wu, Stephanie Leyk, Hanifeh Torabi, Katharina Höhn, Barbara Honecker, Maria del Pilar Martinez Tauler, Dániel Cadar, Thomas Jacobs, Iris Bruchhaus, and Nahla Galal Metwally*
  - iScience. 2023 Jun 15;26(7):107119. doi: 10.1016/j.isci.2023.107119
  - 2023-06-15
- The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity
  - Ma Y, He J, Sieber M, von Frieling J, Bruchhaus I, Baines JF, Bickmeyer U, Roeder T.
  - Commun Biol. 2023 Mar 18;6(1):289. doi: 10.1038/s42003-023-04671-y
  - 2023-03-23
2022
- An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells
  - Alexandra Blancke Soares, Jan Stäcker, Svenja Schwald, Wieteke Hoijmakers, Nahla Galal Metwally, Hanno Schoeler, Sven Flemming, Katharina Höhn, Ulrike Fröhlke, Paolo Mesén-Ramírez, Bärbel Bergmann, Melissa Khosh-Naucke, Iris Bruchhaus, Richárd Bártfai, Tobias Spielmann
  - bioRxiv. 2021.12.03.471078; doi: https://doi.org/10.1101/2021.12.03.471078
  - 2022-12-03
- CD36-A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection
  - Bachmann A, Metwally NG, Allweier J, Cronshagen J, Del Pilar Martinez Tauler M, Murk A, Roth LK, Torabi H, Wu Y, Gutsmann T, Bruchhaus I
  - Microorganisms. 2022 Nov 29;10(12):2356. doi: 10.3390/microorganisms10122356
  - 2022-11-29
- An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis
  - Tahanzadeh N, Knop M, Seidler Y, Dirndorfer S, Lürsen K, Bruchhaus I, Lang R, Rimbach G, Roeder T
  - Aging (Albany NY). 2022 Aug 16;14(16):6427-6448. doi: 10.18632/aging.204218. Epub 2022 Aug 16
  - 2022-08-16
- Ectopic Expression of Plasmodium vivax vir Genes in P. falciparum Affects Cytoadhesion via Increased Expression of Specific var Genes
  - Rehn T, Lubiana P, Nguyen THT, Pansegrau E, Schmitt M, Roth LK, Brehmer J, Roeder T, Cadar D, Metwally NG, Bruchhaus I
  - 2022 Jun 9;10(6):1183. doi: 10.3390/microorganisms10061183
  - 2022-06-09
- HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis
  - Groneberg M, Hoenow S, Marggraff C, Fehling H, Metwally NG, Hansen C, Bruchhaus I, Tiegs G, Sellau J, Lotter H
  - J Hepatol. 2022 Jan;76(1):160-173. doi: 10.1016/j.jhep.2021.09.020
  - 2022-01-01
2021
- Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol
  - Verner Z, Žárský V, Le T, Narayanasamy RK, Rada P, Rozbeský D, Makki A, Belišová D, Hrdý I, Vancová M, Lender C, König C, Bruchhaus I, Tachezy J
  - PLoS Pathog. 2021 Nov 15;17(11):e1010041. doi: 10.1371/journal.ppat.1010041. Online ahead of print
  - 2021-11-15
- Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
  - Raacke M, Kerr A, Dörpinghaus M, Brehmer J, Wu Y, Lorenzen S, Fink C, Jacobs T, Roeder T, Sellau J, Bachmann A, Metwally NG, Bruchhaus I
  - Cells. 2021 Jul 1;10(7):1656. doi: 10.3390/cells10071656
  - 2021-07-01
- Common virulence gene expression in adult first-time infected malaria patients and severe cases
  - Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JAM, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, D Otto T, Lavstsen T, Gilberger TW, Duffy M, Bachmann A
  - Elife. 2021 Apr 28;10:e69040. doi: 10.7554/eLife.69040
  - 2021-04-28
- Taxon-Specific Proteins of the Pathogenic Entamoeba Species E. histolytica and E. nuttalli
  - König C, Honecker B, Wilson IW, Weedall GD, Hall N, Roeder T, Metwally NG, Bruchhaus I
  - Front Cell Infect Microbiol. 2021 Mar 19;11:641472. doi:10.3389/fcimb.2021.641472
  - 2021-03-19
- Analysis of the Interaction Between Plasmodium falciparum-Infected Erythrocytes and Human Endothelial Cells Using a Laminar Flow System, Bioinformatic Tracking and Transcriptome Analysis
  - Wu Y, Bouws P, Lorenzen S, Bruchhaus I, Metwally NG
  - Methods Mol Biol. 2021;2369:187-197. doi: 10.1007/978-1-0716-1681-9_11
  - 2021-01-01
2020
- An Alcohol Dehydrogenase 3 (ADH3) from Entamoeba histolytica Is Involved in the Detoxification of Toxic Aldehydes
  - König C, Meyer M, Lender C, Nehls S, Wallaschkowski T, Holm T, Matthies T, Lercher D, Matthiesen J, Fehling H, Roeder T, Reindl S, Rosenthal M, Metwally NG, Lotter H, Bruchhaus I
  - Microorganisms. 2020 Oct 19;8(10):E1608. doi: 10.3390/microorganisms8101608
  - 2020-10-19
- Androgens Predispose Males to Monocyte-Mediated Immunopathology by Inducing the Expression of Leukocyte Recruitment Factor CXCL1
  - Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H
  - Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y
  - 2020-07-10
- Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling
  - Li Y, Romey-Glüsing R, Tahan Zadeh N, von Frieling J, Hoffmann J, Huebbe P, Bruchhaus I, Rimbach G, Fink C, Roeder T
  - Nutrients. 2020 Apr 22;12(4). pii: E1172. doi: 10.3390/nu12041172
  - 2020-04-22
- Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
  - Lubiana P, Bouws P, Roth LK, Dörpinghaus M, Rehn T, Brehmer J, Wichers JS, Bachmann A, Höhn K, Roeder T, Thye T, Gutsmann T, Burmester T, Bruchhaus I, Metwally NG
  - Sci Rep. 2020 Mar 11;10(1):4548. doi: 10.1038/s41598-020-61388-2
  - 2020-03-11
- Stringent Selection of Knobby Plasmodium falciparum-Infected Erythrocytes during Cytoadhesion at Febrile Temperature
  - Dörpinghaus M, Fürstenwerth F, Roth LK, Bouws P, Rakotonirinalalao M, Jordan V, Sauer M, Rehn T, Pansegrau E, Höhn K, Mesén-Ramírez P, Bachmann A, Lorenzen S, Roeder T, Metwally NG, Bruchhaus I
  - Microorganisms. 2020 Jan 25;8(2). pii: E174. doi:10.3390/microorganisms8020174
  - 2020-01-25
- Gene silencing and overexpression to study pathogenicity factors of Entamoeba histolytica
  - König C, Bruchhaus I
  - Eukaryome impact on human intestine homeostasis and mucosal immunology. Nancy Guillen (Editor), Springer, ISBN 978-3-030-44825-7, DOI 10.1007/978-3-030-44826-4
  - 2020-01-01
2019
- Dissecting the Gene Expression, Localization, Membrane Topology, and Function of the Plasmodium falciparum STEVOR Protein Family
  - Wichers JS, Scholz JAM, Strauss J, Witt S, Lill A, Ehnold LI, Neupert N, Liffner B, Lühken R, Petter M, Lorenzen S, Wilson DW, Löw C, Lavazec C, Bruchhaus I, Tannich E, Gilberger TW, Bachmann A
  - MBio. 2019 Jul 30;10(4):e01500-19. doi: 10.1128/mBio.01500-19
  - 2019-07-30
- An EGFR-induced Drosophila lung tumor model identifies alternative combination treatments
  - Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T
  - Mol Cancer Ther. 2019 Jun 19. pii: molcanther.0168.2019
  - 2019-07-19
- Trigger-induced RNAi gene silencing to identify pathogenicity factors of Entamoeba histolytica
  - Matthiesen J, Lender C, Haferkorn A, Fehling H, Meyer M, Matthies T, Tannich E, Roeder T, Lotter H, Bruchhaus I
  - FASEB J. 2019 Feb;33(2):1658-1668. doi: 10.1096/fj.201801313R
  - 2019-02-01
2018
- Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila
  - Romey-Glüsing R, Li Y, Hoffmann J, von Frieling J, Knop M, Pfefferkorn R, Bruchhaus I, Fink C, Roeder T
  - FASEB J. 2018 Apr;32(4):1993-2003. doi: 10.1096/fj.201700934R
  - 2018-04-23
- Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson's disease model
  - Stephano F, Nolte S, Hoffmann J, El-Kholy S, von Frieling J, Bruchhaus I, Fink C, Roeder T
  - Sci Rep. 2018 Feb 5;8(1):2372. doi: 10.1038/s41598-018-20836-w
  - 2018-02-05
2017
- Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151
  - Metwally NG, Tilly AK, Lubiana P, Roth LK, Dörpinghaus M, Lorenzen S, Schuldt K, Witt S, Bachmann A, Tidow H, Gutsmann T, Burmester T, Roeder T, Tannich E, Bruchhaus I
  - Sci Rep. 2017 Jun 22;7(1):4069. doi: 10.1038/s41598-017-04241-3
  - 2017-07-22
- The role of monoaminergic neurotransmission for metabolic control in the fruit fly Drosophila melanogaster
  - Li Y, Tiedemann L, von Frieling J, Nolte S, El-Kholy S, Stephano F, Gelhaus C, Bruchhaus I, Fink C, Roeder T
  - rontiers in Systems Neuroscience 1: 50. doi: 10.3389/fnsys.2017.00060
  - 2017-01-01
2016
- Octopamine controls starvation resistance, life span and metabolic traits in Drosophila
  - Li Y, Hoffmann J, Li Y, Stephano F, Bruchhaus I, Fink C, Roeder T
  - Sci Rep. 2016 Oct 19:6:35359. doi: 10.1038/srep35359
  - 2016-10-19
- Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation
  - Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I
  - PLoS Pathog. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853
  - 2016-08-30
- Social stress increases the susceptibility to infection in the ant Harpegnathos saltator
  - Schneider SA, Scharffetter C, Wagner AE, Boesch C, Bruchhaus I, Rimbach G, Roeder T
  - Sci Rep. 2016 May 10;6:25800. doi: 10.1038/srep25800
  - 2016-05-10
- IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage
  - Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
  - J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013
  - 2016-05-01
2015
- Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum
  - Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I
  - Sci Rep. 2015 Nov 16;5:16766. doi: 10.1038/srep16766
  - 2015-11-15
- Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles
  - Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H
  - Invest Radiol. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175
  - 2015-10-01
- A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes
  - Bachmann A, Scholz JA, Janßen M, Klinkert MQ, Tannich E, Bruchhaus I, Petter M
  - Malar J. 2015 Jul 16;14:274. doi: 10.1186/s12936-015-0784-2
  - 2015-07-16
- The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins
  - Schulze J, Kwiatkowski M, Borner J, Schlüter H, Bruchhaus I, Burmester T, Spielmann T, Pick C
  - Mol Microbiol. 2015 Jul;97(2):301-14. doi: 10.1111/mmi.13024
  - 2015-05-09
2014
- Transcriptional regionalization of the fruit fly's airway epithelium
  - Faisal MN, Hoffmann J, El-Kholy S, Kallsen K, Wagner C, Bruchhaus I, Fink C, Roeder T
  - PLoS One. 2014 Jul 14;9(7):e102534. doi: 10.1371/journal.pone.0102534
  - 2014-07-14
- Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes
  - Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD
  - Cell Microbiol. 2014 May;16(5):701-8. doi: 10.1111/cmi.12270
  - 2014-05-01
- The cell surface proteome of Entamoeba histolytica
  - Biller L, Matthiesen J, Kühne V, Lotter H, Handal G, Nozaki T, Saito-Nakano Y, Schümann M, Roeder T, Tannich E, Krause E, Bruchhaus I
  - Mol Cell Proteomics. 2014 Jan;13(1):132-44. doi: 10.1074/mcp.M113.031393
  - 2014-01-01
2013
- New phylogenomic data support the monophyly of Lophophorata and an Ectoproct-Phoronid clade and indicate that Polyzoa and Kryptrochozoa are caused by systematic bias
  - Nesnidal MP, Helmkampf M, Meyer A, Witek A, Bruchhaus I, Ebersberger I, Hankeln T, Lieb B, Struck TH, Hausdorf B
  - BMC Evol Biol. 2013 Nov 17;13:253. doi: 10.1186/1471-2148-13-253
  - 2013-11-17
- Overexpression of specific cysteine peptidases confers pathogenicity to a nonpathogenic Entamoeba histolytica clone
  - Matthiesen J, Bär AK, Bartels AK, Marien D, Ofori S, Biller L, Tannich E, Lotter H, Bruchhaus I
  - mBio. 2013 Mar 26;4(2):e00072-13. doi: 10.1128/mBio.00072-13
  - 2013-03-26
- Agent of whirling disease meets orphan worm: phylogenomic analyses firmly place Myxozoa in Cnidaria
  - Nesnidal MP, Helmkampf M, Bruchhaus I, El-Matbouli M, Hausdorf B
  - PLoS One. 2013;8(1):e54576. doi: 10.1371/journal.pone.0054576. Epub 2013 Jan 30
  - 2013-01-30
2012
- Temporal expression and localization patterns of variant surface antigens in clinical Plasmodium falciparum isolates during erythrocyte schizogony
  - Bachmann A, Petter M, Tilly AK, Biller L, Uliczka KA, Duffy MF, Tannich E, Bruchhaus I
  - PLoS One. 2012;7(11):e49540. doi: 10.1371/journal.pone.0049540
  - 2012-11-15
- Genomic diversity of the human intestinal parasite Entamoeba histolytica
  - Weedall GD, Clark CG, Koldkjaer P, Kay S, Bruchhaus I, Tannich E, Paterson S, Hall N
  - Genome Biol. 2012 May 25;13(5):R38. doi: 10.1186/gb-2012-13-5-r38
  - 2012-05-25
- The cysteine protease inhibitors EhICP1 and EhICP2 perform different tasks in the regulation of endogenous protease activity in trophozoites of Entamoeba histolytica
  - Šarić M, Irmer H, Eckert D, Bär AK, Bruchhaus I, Scholze H
  - Protist. 2012 Jan;163(1):116-28. doi: 10.1016/j.protis.2011.01.003
  - 2012-01-01
2011
- The complete mitochondrial genome of Flustra foliacea (Ectoprocta, Cheilostomata) - compositional bias affects phylogenetic analyses of lophotrochozoan relationships
  - Nesnidal MP, Helmkampf M, Bruchhaus I, Hausdorf B
  - BMC Genomics. 2011 Nov 23;12:572. doi: 10.1186/1471-2164-12-572
  - 2011-11-23
- Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patients
  - Bachmann A, Predehl S, May J, Harder S, Burchard GD, Gilberger TW, Tannich E, Bruchhaus I
  - Cell Microbiol. 2011 Sep;13(9):1397-409. doi: 10.1111/j.1462-5822.2011.01629.x
  - 2011-09-13
- Phylogenomic analyses of malaria parasites and evolution of their exported proteins
  - Pick C, Ebersberger I, Spielmann T, Bruchhaus I, Burmester T
  - BMC Evol Biol. 2011 Jun 15;11:167. doi: 10.1186/1471-2148-11-167
  - 2011-06-15
2010
- Compositional heterogeneity and phylogenomic inference of metazoan relationships
  - Nesnidal MP, Helmkampf M, Bruchhaus I, Hausdorf B
  - Mol Biol Evol. 2010 Sep;27(9):2095-104. doi: 10.1093/molbev/msq097
  - 2010-09-10
- Phylogenetic relationships within the lophophorate lineages (Ectoprocta, Brachiopoda and Phoronida)
  - Hausdorf B, Helmkampf M, Nesnidal MP, Bruchhaus I
  - Mol Phylogenet Evol. 2010 Jun;55(3):1121-7. doi: 10.1016/j.ympev.2009.12.022
  - 2010-06-01
- The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica
  - Dolezal P, Dagley MJ, Kono M, Wolynec P, Likić VA, Foo JH, Sedinová M, Tachezy J, Bachmann A, Bruchhaus I, Lithgow T
  - PLoS Pathog. 2010 Mar 19;6(3):e1000812. doi: 10.1371/journal.ppat.1000812
  - 2010-03-19
- tRNA gene sequences are required for transcriptional silencing in Entamoeba histolytica
  - Irmer H, Hennings I, Bruchhaus I, Tannich E
  - Eukaryot Cell. 2010 Feb;9(2):306-14. doi: 10.1128/EC.00248-09
  - 2010-02-01
- Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity
  - Roeder T, Stanisak M, Gelhaus C, Bruchhaus I, Grötzinger J, Leippe M
  - Dev Comp Immunol. 2010 Feb;34(2):203-9. doi: 10.1016/j.dci.2009.09.010. Epub 2009 Oct 21
  - 2010-02-01
- Characterization of a subunit of the outer dynein arm docking complex necessary for correct flagellar assembly in Leishmania donovani
  - Harder S, Thiel M, Clos J, Bruchhaus I
  - PLoS Negl Trop Dis. 2010 Jan 26;4(1):e586. doi: 10.1371/journal.pntd.0000586
  - 2010-01-26
- Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties
  - Biller L, Davis PH, Tillack M, Matthiesen J, Lotter H, Stanley SL Jr, Tannich E, Bruchhaus I
  - BMC Genomics. 2010 Jan 26;11:63. doi: 10.1186/1471-2164-11-63
  - 2010-01-26
2009
- Absence of erythrocyte sequestration and lack of multicopy gene family expression in Plasmodium falciparum from a splenectomized malaria patient
  - Bachmann A, Esser C, Petter M, Predehl S, von Kalckreuth V, Schmiedel S, Bruchhaus I, Tannich E
  - PLoS One. 2009 Oct 14;4(10):e7459. doi: 10.1371/journal.pone.0007459
  - 2009-10-14
- Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties
  - Biller L, Schmidt H, Krause E, Gelhaus C, Matthiesen J, Handal G, Lotter H, Janssen O, Tannich E, Bruchhaus I
  - Proteomics. 2009 Sep;9(17):4107-20. doi: 10.1002/pmic.200900022
  - 2009-09-09
- Major cysteine peptidases of Entamoeba histolytica are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity
  - Irmer H, Tillack M, Biller L, Handal G, Leippe M, Roeder T, Tannich E, Bruchhaus I
  - Mol Microbiol. 2009 May;72(3):658-67. doi: 10.1111/j.1365-2958.2009.06672.x
  - 2009-05-01
2008
- An Entamoeba cysteine peptidase specifically expressed during encystation
  - Ebert F, Bachmann A, Nakada-Tsukui K, Hennings I, Drescher B, Nozaki T, Tannich E, Bruchhaus I
  - Parasitol Int. 2008 Dec;57(4):521-4. doi: 10.1016/j.parint.2008.07.002. Epub 2008 Aug 5
  - 2008-12-01
- Phylogenomic analyses of lophophorates (brachiopods, phoronids and bryozoans) confirm the Lophotrochozoa concept
  - Helmkampf M, Bruchhaus I, Hausdorf B
  - Proc Biol Sci. 2008 Aug 22;275(1645):1927-33. doi: 10.1098/rspb.2008.0372
  - 2008-08-22
- Involvement of a Leishmania thymidine kinase in flagellum formation, promastigote shape and growth as well as virulence
  - Thiel M, Harder S, Wiese M, Kroemer M, Bruchhaus I
  - Mol Biochem Parasitol. 2008 Apr;158(2):152-62. doi: 10.1016/j.molbiopara.2007.12.005
  - 2008-04-01
- Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum
  - Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW
  - Infect Immun. 2008 Mar;76(3):879-87. doi: 10.1128/IAI.00144-07
  - 2008-03-01
- Multigene analysis of lophophorate and chaetognath phylogenetic relationships
  - Helmkampf M, Bruchhaus I, Hausdorf B
  - Mol Phylogenet Evol. 2008 Jan;46(1):206-14. doi: 10.1016/j.ympev.2007.09.004
  - 2008-01-01
2007
- Spiralian phylogenomics supports the resurrection of Bryozoa comprising Ectoprocta and Entoprocta
  - Hausdorf B, Helmkampf M, Meyer A, Witek A, Herlyn H, Bruchhaus I, Hankeln T, Struck TH, Lieb B
  - Mol Biol Evol. 2007 Dec;24(12):2723-9. doi: 10.1093/molbev/msm214
  - 2007-12-01
- Protozoan parasites: programmed cell death as a mechanism of parasitism
  - Bruchhaus I, Roeder T, Rennenberg A, Heussler VT
  - Trends Parasitol. 2007 Aug;23(8):376-83. doi: 10.1016/j.pt.2007.06.004
  - 2007-08-23
- The Entamoeba histolytica genome: primary structure and expression of proteolytic enzymes
  - Tillack M, Biller L, Irmer H, Freitas M, Gomes MA, Tannich E, Bruchhaus I
  - BMC Genomics. 2007 Jun 14;8:170. doi: 10.1186/1471-2164-8-170
  - 2007-06-14
- Proteomic analysis of Entamoeba histolytica
  - Tolstrup J, Krause E, Tannich E, Bruchhaus I
  - Parasitology. 2007 Feb;134(Pt 2):289-98. doi: 10.1017/S0031182006001442
  - 2007-02-01
- Structure and content of the Entamoeba histolytica genome
  - Clark CG, Alsmark UC, Tazreiter M, Saito-Nakano Y, Ali V, Marion S, Weber C, Mukherjee C, Bruchhaus I, Tannich E, Leippe M, Sicheritz-Ponten T, Foster PG, Samuelson J, Noël CJ, Hirt RP, Embley TM, Gilchrist CA, Mann BJ, Singh U, Ackers JP, Bhattacharya S, Bhattacharya A, Lohia A, Guillén N, Duchêne M, Nozaki T, Hall N
  - Adv Parasitol. 2007;65:51-190. doi: 10.1016/S0065-308X(07)65002-7
  - 2007-01-01
2006
- The second cysteine protease inhibitor, EhICP2, has a different localization in trophozoites of Entamoeba histolytica than EhICP1
  - Sarić M, Vahrmann A, Bruchhaus I, Bakker-Grunwald T, Scholze H
  - Parasitol Res. 2006 Dec;100(1):171-4. doi: 10.1007/s00436-006-0206-z
  - 2006-12-01
- Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica
  - Tillack M, Nowak N, Lotter H, Bracha R, Mirelman D, Tannich E, Bruchhaus I
  - Mol Biochem Parasitol. 2006 Sep;149(1):58-64. doi: 10.1016/j.molbiopara.2006.04.009
  - 2006-09-01
- Expression of a mitochondrial peroxiredoxin prevents programmed cell death in Leishmania donovani
  - Harder S, Bente M, Isermann K, Bruchhaus I
  - Eukaryot Cell. 2006 May;5(5):861-70. doi: 10.1128/EC.5.5.861-870.2006
  - 2006-05-01
2005
- Identification of EhICP1, a chagasin-like cysteine protease inhibitor of Entamoeba histolytica
  - Riekenberg S, Witjes B, Sarić M, Bruchhaus I, Scholze H
  - FEBS Lett. 2005 Mar 14;579(7):1573-8. doi: 10.1016/j.febslet.2005.01.067
  - 2005-03-14
- The genome of the protist parasite Entamoeba histolytica
  - Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillén N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA Jr, Clark CG, Embley TM, Barrell B, Fraser CM, Hall N
  - Nature. 2005 Feb 24;433(7028):865-8. doi: 10.1038/nature03291
  - 2005-02-24
2004
- Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity
  - Nowak N, Lotter H, Tannich E, Bruchhaus I
  - J Biol Chem. 2004 Sep 10;279(37):38260-6. doi: 10.1074/jbc.M405308200
  - 2004-09-10
- A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans
  - Isermann K, Liebau E, Roeder T, Bruchhaus I
  - J Mol Biol. 2004 May 7;338(4):745-55. doi: 10.1016/j.jmb.2004.03.021
  - 2004-05-07
- Entamoeba histolytica trophozoites transfer lipophosphopeptidoglycans to enteric cell layers
  - Lauwaet T, Oliveira MJ, De Bruyne G, Bruchhaus I, Duchêne M, Mareel M, Leroy A
  - Int J Parasitol. 2004 Apr;34(5):549-56. doi: 10.1016/j.ijpara.2003.11.013
  - 2004-04-01
- Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo
  - Ghosh S, Chan JM, Lea CR, Meints GA, Lewis JC, Tovian ZS, Flessner RM, Loftus TC, Bruchhaus I, Kendrick H, Croft SL, Kemp RG, Kobayashi S, Nozaki T, Oldfield E
  - J Med Chem. 2004 Jan 1;47(1):175-87. doi: 10.1021/jm030084x
  - 2004-01-01
2003
- Developmentally induced changes of the proteome in the protozoan parasite Leishmania donovani
  - Bente M, Harder S, Wiesgigl M, Heukeshoven J, Gelhaus C, Krause E, Clos J, Bruchhaus I
  - Proteomics. 2003 Sep;3(9):1811-29. doi: 10.1002/pmic.200300462
  - 2003-09-01
- The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation
  - Bruchhaus I, Loftus BJ, Hall N, Tannich E
  - Eukaryot Cell. 2003 Jun;2(3):501-9. doi: 10.1128/EC.2.3.501-509.2003
  - 2003-06-01
2002
- Differential gene expression in Entamoeba histolytica isolated from amoebic liver abscess
  - Bruchhaus I, Roeder T, Lotter H, Schwerdtfeger M, Tannich E
  - Mol Microbiol. 2002 May;44(4):1063-72. doi: 10.1046/j.1365-2958.2002.02941.x
  - 2002-05-01
- Recombinant expression and purification of an enzymatically active cysteine proteinase of the protozoan parasite Entamoeba histolytica
  - Hellberg A, Nowak N, Leippe M, Tannich E, Bruchhaus I
  - Protein Expr Purif. 2002 Feb;24(1):131-7. doi: 10.1006/prep.2001.1548
  - 2002-02-01
2001
- Comparative proteome analysis of Leishmania donovani at different stages of transformation from promastigotes to amastigotes
  - Thiel M, Bruchhaus I
  - Med Microbiol Immunol. 2001 Nov;190(1-2):33-6. doi: 10.1007/s004300100075
  - 2001-11-01
- Introns of Entamoeba histolytica and Entamoeba dispar
  - Wilihoeft U, Campos-Góngora E, Touzni S, Bruchhaus I, Tannich E
  - Protist. 2001 Jul;152(2):149-56. doi: 10.1078/1434-4610-00053
  - 2001-07-15
- Overexpression of cysteine proteinase 2 in Entamoeba histolytica or Entamoeba dispar increases amoeba-induced monolayer destruction in vitro but does not augment amoebic liver abscess formation in gerbils
  - Hellberg A, Nickel R, Lotter H, Tannich E, Bruchhaus I
  - Cell Microbiol. 2001 Jan;3(1):13-20. doi: 10.1046/j.1462-5822.2001.00086.x
  - 2001-01-01
2000
- A simple and reliable 5'-RACE approach
  - Schramm G, Bruchhaus I, Roeder T
  - Nucleic Acids Res. 2000 Nov 15;28(22):E96. doi: 10.1093/nar/28.22.e96
  - 2000-11-15
- Superoxide dismutase reduces susceptibility to metronidazole of the pathogenic protozoan Entamoeba histolytica under microaerophilic but not under anaerobic conditions
  - Wassmann C, Bruchhaus I
  - Arch Biochem Biophys. 2000 Apr 1;376(1):236-8. doi: 10.1006/abbi.2000.1707
  - 2000-04-01
- Two major 'higher molecular mass proteinases' of Entamoeba histolytica are identified as cysteine proteinases 1 and 2
  - Hellberg A, Leippe M, Bruchhaus I
  - Mol Biochem Parasitol. 2000 Feb 5;105(2):305-9. doi: 10.1016/s0166-6851(99)00194-2
  - 2000-02-05
1999
- Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase
  - Wassmann C, Hellberg A, Tannich E, Bruchhaus I
  - J Biol Chem. 1999 Sep 10;274(37):26051-6. doi: 10.1074/jbc.274.37.26051
  - 1999-09-10
- Verification of differential gene transcription using virtual northern blotting
  - Franz O, Bruchhaus I, Roeder T
  - Nucleic Acids Res. 1999 Jun 1;27(11):e3. doi: 10.1093/nar/27.11.e3
  - 1999-06-01
- Primary sequence of a putative non-ATPase subunit of the 26S proteasome from Entamoeba histolytica is similar to the human and yeast S2 subunit
  - Hellberg A, Sommer A, Bruchhaus I
  - Parasitol Res. 1999 May;85(5):417-20. doi: 10.1007/s004360050569
  - 1999-05-01
1998
- Isolation of ultrapure supercoiled plasmid-DNA using preparative electrophoresis
  - Roeder T, Görich D, Roeder NP, Bruchhaus I
  - Electrophoresis. 1998 Jul;19(10):1575-6. doi: 10.1002/elps.1150191009
  - 1998-07-01
- Recombinant expression and biochemical characterization of an NADPH:flavin oxidoreductase from Entamoeba histolytica
  - Bruchhaus I, Richter S, Tannich E
  - Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1217-21. doi: 10.1042/bj3301217
  - 1998-03-15
- Isolation and molecular characterization of a surface-bound proteinase of Entamoeba histolytica
  - Jacobs T, Bruchhaus I, Dandekar T, Tannich E, Leippe M
  - Mol Microbiol. 1998 Jan;27(2):269-76. doi: 10.1046/j.1365-2958.1998.00662.x
  - 1998-01-27
1997
- Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica
  - Bruchhaus I, Richter S, Tannich E
  - Biochem J. 1997 Sep 15;326 ( Pt 3)(Pt 3):785-9. doi:10.1042/bj3260785
  - 1997-09-15
- Characterization of two E. histolytica proteins that inactivate reactive oxygen species
  - Bruchhaus I, Richter S, Tannich E
  - Arch Med Res. 1997;28 Spec No:91-2
  - 1997-01-01
1996
- Entamoeba histolytica and Entamoeba dispar: differences in numbers and expression of cysteine proteinase genes
  - Bruchhaus I, Jacobs T, Leippe M, Tannich E
  - Mol Microbiol. 1996 Oct;22(2):255-63. doi: 10.1046/j.1365-2958.1996.00111.x
  - 1996-06-22
- Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues
  - Bruchhaus I, Jacobs T, Denart M, Tannich E
  - Biochem J. 1996 May 15;316 ( Pt 1)(Pt 1):57-63. doi: 10.1042/bj3160057
  - 1996-05-01
- A gene highly homologous to ACP1 encoding cysteine proteinase 3 in Entamoeba histolytica is present and expressed in E. dispar
  - Bruchhaus I, Tannich E
  - Parasitol Res. 1996;82(2):189-92. doi: 10.1007/s004360050093
  - 1996-01-01
1995
- Identification of an Entamoeba histolytica gene encoding a protein homologous to prokaryotic disulphide oxidoreductases
  - Bruchhaus I, Tannich E
  - Mol Biochem Parasitol. 1995 Mar;70(1-2):187-91. doi: 10.1016/0166-6851(94)00214-8
  - 1995-03-01
1994
- Purification and molecular characterization of the NAD(+)-dependent acetaldehyde/alcohol dehydrogenase from Entamoeba histolytica
  - Bruchhaus I, Tannich E
  - Mol Biochem Parasitol. 1994 Oct;67(2):281-8. doi: 10.1016/0166-6851(94)00143-x
  - 1994-10-01
1993
- Unusual gene organization in the protozoan parasite Entamoeba histolytica
  - Bruchhaus I, Leippe M, Lioutas C, Tannich E
  - DNA Cell Biol. 1993 Dec;12(10):925-33. doi: 10.1089/dna.1993.12.925
  - 1993-12-01
- Primary structure of the pyruvate phosphate dikinase in Entamoeba histolytica
  - Bruchhaus I, Tannich E
  - Mol Biochem Parasitol. 1993 Nov;62(1):153-6. doi: 10.1016/0166-6851(93)90193-2
  - 1993-11-01
- Analysis of the genomic sequence encoding the 29-kDa cysteine-rich protein of Entamoeba histolytica
  - Bruchhaus I, Tannich E
  - Trop Med Parasitol. 1993 Jun;44(2):116-8
  - 1993-06-01
1992
- Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum
  - Komuniecki R, Bruchhaus I, Ilg T, Wilson K, Zhang Y, Fairlamb AH
  - Mol Biochem Parasitol. 1992 Apr;51(2):331-3. doi: 10.1016/0166-6851(92)90084-w
  - 1992-04-01

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