Unsere Publikationen auf einen Blick
2024
Lassa virus persistence with high viral titres following experimental infection in its natural reservoir host, Mastomys natalensis
- Hoffmann C, Krasemann S, Wurr S, Hartmann K, Adam E, Bockholt S, Müller J, Günther S, Oestereich L
- Nature Communictaions. (2024)15:9319. doi:10.1038/s41467-024-53616-4
Virus load kinetics in Lassa fever patients treated with ribavirin: a retrospective cohort study from Southern Nigeria
- Ogbaini-Emovon E, Akpede G, Okogbenin S, Osagiede E, Tobin E, Asogun D, Okokhere P, Okonofua M, Akpede N, Akhideno P, Erameh C, Rafiu M, Azubuike C, Iraoya K, Iruolagbe C, Erohubie C, Ahmed D, Ediawe O, Okoguale J, Eifediyi R, Odia I, Agbuko J, Adomeh D, Odike MAC, Ovienria W, Elkanem A, Muoebenam BE, Ojide CK, Pallasch E, Müller J, Hinzmann J, Günther S, Pahlmann M, Thielebein A, Duraffour S, Oestereich L, Krumkamp R
- Open Forum Infect Dis. 2024 Oct 15;11(10):ofae575. doi:10.1093/ofid/ofae575
Intracellular lipid droplets are exploited by Junín virus: a nucleoprotein-dependent process
- Vazquez CA, Escudero-Pérez B, Hayashi JM, Leon KE, Moreira JP, Cataña MAC, Groseth A, Ott M, Oestereich L, Muñoz-Fontela C, Garcia CC, Cordo SM
- J Cell Sci.(2024)137(19):jcs261745. doi: 10.1242/jcs.261745.
Electroencephalography in emerging viral infections: lessons learned from implementing an EEG unit in a Lassa fever isolation ward in Nigeria
- Mueller HCS, Oshomah Erameh C, Gelderblom M, Edeawe OI, Akupasubi OG, Ekoyata EU, Aiterebhe UM, Okoeguale J, Guenther S, Oestereich L, Ramharter M, Okogbenin S, Omansen T
- PLoS Negl Trop Dis. 2024 Oct 2;18(10):e0012522. doi: 10.1371/journal.pntd.0012522
Ebola virus infection of Flt3-dependent, conventional dendritic cells and antigen cross-presentation leads to high levels of T-cell activation
- Niemetz L, Bodmer BS, Olal C, Escudero-Pérez B, Hoehn K, Bencsik A, Vickers M, Oestereich L, Hoenen T, Muñoz-Fontela C
- J Infect Dis. 2024 Sep 25:jiae441. doi: 10.1093/infdis/jiae441
Third International Conference on Crimean-Congo hemorrhagic fever in Thessaloniki, Greece, September 19-21,2023
- Welch SR, Garrison AR, Bente DA, Burt F, D'Addiego J, Devignot S, Dowall S, Fischer K, Hawman DW, Hewson R, Mirazimi A, Oestereich L, Vatansever Z, Spengler JR, Papa A
- Antiviral Research. 2024 Feb 29; 105844. doi:j.antiviral.2024.105844
2023
Luminescent reporter cells enable the identification of broad-spectrum antivirals against emerging viruses
- Löw K, Möller R, Stegmann C, Becker M, Rehburg L, Obernolte H, Schaudien D, Oestereich L, Braun A, Kunz S, Gerold G
- J Med Virol. 2023 Nov;95(11):e29211. doi: 10.1002/jmv.29211
Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis)
- Hansen F, Vučak M, Nichols J, Hughes J, Bane S, Camiolo S, da Silva Filipe A, Ostermann E, Staliunaite L, Chan B, Mauch T, Sogoba N, Streblow DN, Voigt S, Oestereich L, Ehlers B, Redwood AJ, Feldmann H, Brune W, Rosenke K, Jarvis MA, Davison AJ
- J Gen Virol. 2023 Aug;104(8):001873. doi: 10.1099/jgv.0.001873
Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection
- Oestereich L, Müller-Kräuter H, Pallasch E, Strecker T
- Viruses. 2023 Jun 26;15(7):1436. doi: 10.3390/v15071436
Seroepidemiology of Lassa virus in pregnant women in Southern Nigeria: A prospective hospital-based cohort study
- Kayem ND, Okogbenin S, Okoeguale J, Momoh M, Njoku A, Eifediyi R, Enodiana X, Ngwu H, Irhiogbe W, Ighodalo Y, Olokor T, Odigie G, Castle L, Duraffour S, Oestereich L, Dahal P, Ariana P, Gunther S, Horby P
- PLoS Negl Trop Dis. 2023 May 22;17(5):e0011354. doi: 10.1371/journal.pntd.0011354
A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells
- Soh TK, Pfefferle S, Wurr S, von Possel R, Oestereich L, Rieger T, Uetrecht C, Rosenthal M, Bosse JB
- PLoS One. 2023 May 10; 18(5):e0274065. doi:10.1371/journal.pone.0274065
Focussed Assessment with Sonography in acute Lassa Fever (FASLa): Development of a point-of-care protocol and description of common ultrasound findings
- Erameh CO, Koch T, Edeawe OI, Oestereich L, Omansen T, Jochum J, Adomeh DI, Ikponmwonsa O, Aire C, Pahlmann M, Asogun DA, Ogbaini-Emovon E, Okogbenin SA, Günther S, Ramharter M, Akideno PE, Kreuels B
- J Infect. 2023 Apr 17:S0163-4453(23)00208-6. doi: 10.1016/j.jinf.2023.04.008
Transplacental transfer of Lassa IgG antibodies in pregnant women in Southern Nigeria: A prospective hospital-based cohort study
- Kayem ND, Okogbenin S, Okoeguale J, Eigbefoh J, Ikheloa J, Eifediyi R, Enodiana X, Olorogbogo OE, Aikpokpo I, Ighodalo Y, Olokor T, Odigie G, Castle L, Duraffour S, Oestereich L, Dahal P, Ariana P, Gunther S, Horby P
- PLoS Negl Trop Dis. 2023 Apr 13;17(4):e0011209. doi: 10.1371/journal.pntd.0011209
2022
Understanding Host-Virus Interactions: Assessment of Innate Immune Responses in Mastomys natalensis Cells after Arenavirus Infection
- Brinkmann NM, Hoffmann C, Wurr S, Pallasch E, Hinzmann J, Ostermann E, Brune W, Eskes ME, Jungblut L, Günther S, Unrau L, Oestereich L
- Viruses. 2022 Sep 8;14(9):1986. doi: 10.3390/v14091986
Two Cases of Lassa Fever Successfully Treated with Ribavirin and Adjunct Dexamethasone for Concomitant Infections
- Okogbenin S, Erameh C, Okoeguale J, Edeawe O, Ekuaze E, Iraoyah K, Agho J, Groger M, Kreuels B, Oestereich L, Babatunde FO, Akhideno P, Günther S, Ramharter M, Omansen T
- Emerg Infect Dis. 2022 Oct;28(10):2060-2063. doi: 10.3201/eid2810.220625
Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors
- Rottstegge M, Tipton T, Oestereich L, Ruibal P, Nelson EV, Olal C, Port JR, Seibel J, Pallasch E, Bockholt S, Koundouno FR, Boré JA, Rodríguez E, Escudero-Pérez B, Günther S, Carroll MW, Muñoz-Fontela C
- J Virol. 2022 Sep 28;96(18):e0057422. doi: 10.1128/jvi.00574-22
Establishment of Recombinant Trisegmented Mopeia Virus Expressing Two Reporter Genes for Screening of Mammarenavirus Inhibitors
- Oestereich L, Wurr S, Becker-Ziaja B, Bockholt S, Pahlmann M, Cadar D, Kümmerer BM, Günther S, Kerber R
- Viruses. 2022 Aug 25;14(9):1869. doi:10.3390/v14091869
Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria
- Groger M, Akhideno P, Kleist CJ, Babatunde FO, Edeawe O, Hinzmann J, Akhigbe T, Nwatuzor J, Eifediyi G, Müller J, Hinrichs M, Pahlmann M, Sarpong FN, Wagner C, Thielebein A, Aihonwalan L, Koch T, Riedner M, Ogbaini-Emovon E, Okogbenin S, Günther S, Wicha SG, Ramharter M, Oestereich L, Duraffour S, Erameh C
- Clin Infect Dis. 2023 Feb 8;76(3):e841-e848. doi: 10.1093/cid/ciac578
Detection of Lassa Virus-Reactive IgG Antibodies in Wild Rodents: Validation of a Capture Enzyme-Linked Immunological Assay
- Soubrier H, Bangura U, Hoffmann C, Olayemi A, Adesina AS, Günther S, Oestereich L, Fichet-Calvet E
- Viruses. 2022 May 7;14(5):993. doi: 10.3390/v14050993
Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera
- Deschermeier C, Ehmen C, von Possel R, Murawski C, Rushton B, Amuasi J, Sarpong N, Maiga-Ascofaré O, Rakotozandrindrainy R, Asogun D, Ighodalo Y, Oestereich L, Duraffour S, Pahlmann M, Emmerich P
- J Clin Microbiol. 2022 Jun 15;60(6):e0007522. doi: 10.1128/jcm.00075-22
Virus persistence after recovery from acute Lassa fever in Nigeria: a 2-year interim analysis of a prospective longitudinal cohort study
- Thielebein A, Ighodalo Y, Taju A, Olokor T, Omiunu R, Esumeh R, Ebhodaghe P, Ekanem A, Igenegbale G, Giwa R, Renevey A, Hinzmann J, Müller J, Pallasch E, Pahlmann M, Guedj J, Nwatuzor J, Femi Babatunde O, Adomeh DI, Asogun D, Akpede N, Okogbenin S, Günther S, Oestereich L, Duraffour S, Ogbaini-Emovon E
- Lancet Microbe. 2022 Jan;3(1):e32-e40. doi: 10.1016/S2666-5247(21)00178-6
2021
Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl(4) Exposure in Mice
- Unrau L, Endig J, Goltz D, Sprezyna P, Ulrich H, Hagenstein J, Geers B, Kaftan K, Heukamp LC, Tiegs G, Diehl L
- Int J Mol Sci. 2021 Oct 27;22(21):11575. doi: 10.3390/ijms222111575
Validation of Inactivation Methods for Arenaviruses
- Olschewski S, Thielebein A, Hoffmann C, Blake O, Müller J, Bockholt S, Pallasch E, Hinzmann J, Wurr S, Neddersen N, Rieger T, Günther S, Oestereich L
- Viruses. 2021 May 24;13(6):968. doi: 10.3390/v13060968
Experimental Morogoro Virus Infection in Its Natural Host, Mastomys natalensis
- Hoffmann C, Wurr S, Pallasch E, Bockholt S, Rieger T, Günther S, Oestereich L
- Viruses. 2021 May 7;13(5):851. doi: 10.3390/v13050851
Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study
- Strampe J, Asogun DA, Speranza E, Pahlmann M, Soucy A, Bockholt S, Pallasch E, Becker-Ziaja B, Duraffour S, Bhadelia N, Ighodalo Y, Oyakhilome J, Omomoh EO, Olokor T, Adomeh DI, Ikponwonsa O, Aire C, Tobin E, Akpede N, Okokhere PO, Okogbenin SA, Akpede GO, Muñoz-Fontela C, Ogbaini-Emovon E, Günther S, Connor JH, Oestereich L
- Lancet Infect Dis. 2021 Jan 20;21(6):876-886. doi: 10.1016/S1473-3099(20)30737-4
Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR
- Olearo F, Nörz D, Heinrich F, Sutter JP, Roedl K, Schultze A, Wiesch JSZ, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, Lütgehetmann M
- J Clin Virol. 2021 Apr;137:104782. doi: 10.1016/j.jcv.2021.104782
Limited specificity of commercially available SARS-CoV-2 IgG ELISAs in serum samples of African origin
- Emmerich P, Murawski C, Ehmen C, von Possel R, Pekarek N, Oestereich L, Duraffour S, Pahlmann M, Struck N, Eibach D, Krumkamp R, Amuasi J, Maiga-Ascofaré O, Rakotozandrindrainy R, Asogun D, Ighodalo Y, Kann S, May J, Tannich E, Deschermeier C
- Trop Med Int Health. 2021 Jun;26(6):621-631. doi: 10.1111/tmi.13569
2020
Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
- Nörz D, Frontzek A, Eigner U, Oestereich L, Wichmann D, Kluge S, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M
- J Clin Virol. 2020 Nov;132:104650. doi: 10.1016/j.jcv.2020.104650
SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany
- Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch JK, Lütgehetmann M, Fischer N
- Clin Microbiol Infect. 2021 Jan;27(1):130.e5-130.e8. doi: 10.1016/j.cmi.2020.09.034
Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues
- Port JR, Wozniak DM, Oestereich L, Pallasch E, Becker-Ziaja B, Müller J, Rottstegge M, Olal C, Gómez-Medina S, Oyakhliome J, Ighodalo Y, Omomoh E, Olokor T, Adomeh DI, Asogun D, Ogbani-Emovon E, Hartmann K, Krasemann S, Nelson EV, Escudero-Pérez B, McElroy AK, Günther S, Muñoz-Fontela C
- J Virol. 2020 Oct 14;94(21):e01367-20. doi: 10.1128/JVI.01367-20
Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity
- Müller H, Fehling SK, Dorna J, Urbanowicz RA, Oestereich L, Krebs Y, Kolesnikova L, Schauflinger M, Krähling V, Magassouba N, Fichet-Calvet E, Ball JK, Kaufmann A, Bauer S, Becker S, von Messling V, Strecker T
- NPJ Vaccines. 2020 August 04; 5(1):71. doi:10.1038/s41541-020-00219-x
Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus
- Yadouleton A, Picard C, Rieger T, Loko F, Cadar D, Kouthon EC, Job EO, Bankolé H, Oestereich L, Gbaguidi F, Pahlman M, Becker-Ziaja B, Journeaux A, Pannetier D, Mély S, Mundweiler S, Thomas D, Kohossi L, Saizonou R, Kakaï CG, Da Silva M, Kossoubedie S, Kakonku AL, M'Pelé P, Gunther S, Baize S, Fichet-Calvet E
- Emerg Microbes Infect. 2020 Dec;9(1):1761-1770. doi: 10.1080/22221751.2020.1796528
Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany
- Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N
- Microbiol Resour Announc. 2020 Jun 4;9(23):e00520-20. doi: 10.1128/MRA.00520-20
Field evaluation of a Pan-Lassa rapid diagnostic test during the 2018 Nigerian Lassa fever outbreak
- Boisen ML, Uyigue E, Aiyepada J, Siddle KJ, Oestereich L, Nelson DKS, Bush DJ, Rowland MM, Heinrich ML, Eromon P, Kayode AT, Odia I, Adomeh DI, Muoebonam EB, Akhilomen P, Okonofua G, Osiemi B, Omoregie O, Airende M, Agbukor J, Ehikhametalor S, Aire CO, Duraffour S, Pahlmann M, Böhm W, Barnes KG, Mehta S, Momoh M, Sandi JD, Goba A, Folarin OA, Ogbaini-Emovan E, Asogun DA, Tobin EA, Akpede GO, Okogbenin SA, Okokhere PO, Grant DS, Schieffelin JS, Sabeti PC, Günther S, Happi CT, Branco LM, Garry RF
- Sci Rep. 2020 May 26;10(1):8724. doi: 10.1038/s41598-020-65736-0
Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
- Erameh C, Edeawe O, Akhideno P, Eifediyi G, Omansen TF, Wagner C, Sarpong F, Koch T, Wicha S, Kurth F, Duraffour S, Oestereich L, Pahlmann M, Okogbenin S, Ogbaini-Emovon E, Günther S, Ramharter M, Groger M
- BMJ Open. 2020 Apr 16;10(4):e036936. doi: 10.1136/bmjopen-2020-036936
Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis
- Schulte R, Wohlleber D, Unrau L, Geers B, Metzger C, Erhardt A, Tiegs G, van Rooijen N, Heukamp LC, Klotz L, Knolle PA, Diehl L
- Int J Mol Sci. 2020 Apr 5;21(7):2523. doi: 10.3390/ijms21072523
Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials
- Madelain V, Mentré F, Baize S, Anglaret X, Laouénan C, Oestereich L, Nguyen THT, Malvy D, Piorkowski G, Graw F, Günther S, Raoul H, de Lamballerie X, Guedj J
- CPT Pharmacometrics Syst Pharmacol. 2020 May;9(5):258-271. doi: 10.1002/psp4.12510
Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol
- Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Wendel HG, Hartmann RK, Ziebuhr J, Grünweller A
- Antiviral Res. 2020 Mar;175:104706. doi: 10.1016/j.antiviral.2020.104706
2019
Phylogeography of Lassa Virus in Nigeria
- Ehichioya DU, Dellicour S, Pahlmann M, Rieger T, Oestereich L, Becker-Ziaja B, Cadar D, Ighodalo Y, Olokor T, Omomoh E, Oyakhilome J, Omiunu R, Agbukor J, Ebo B, Aiyepada J, Ebhodaghe P, Osiemi B, Ehikhametalor S, Akhilomen P, Airende M, Esumeh R, Muoebonam E, Giwa R, Ekanem A, Igenegbale G, Odigie G, Okonofua G, Enigbe R, Omonegho Yerumoh E, Pallasch E, Bockholt S, Kafetzopoulou LE, Duraffour S, Okokhere PO, Akpede GO, Okogbenin SA, Odia I, Aire C, Akpede N, Tobin E, Ogbaini-Emovon E, Lemey P, Adomeh DI, Asogun DA, Günther S
- J Virol. 2019 Oct 15;93(21):e00929-19. doi: 10.1128/JVI.00929-19
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak
- Kafetzopoulou LE, Pullan ST, Lemey P, Suchard MA, Ehichioya DU, Pahlmann M, Thielebein A, Hinzmann J, Oestereich L, Wozniak DM, Efthymiadis K, Schachten D, Koenig F, Matjeschk J, Lorenzen S, Lumley S, Ighodalo Y, Adomeh DI, Olokor T, Omomoh E, Omiunu R, Agbukor J, Ebo B, Aiyepada J, Ebhodaghe P, Osiemi B, Ehikhametalor S, Akhilomen P, Airende M, Esumeh R, Muoebonam E, Giwa R, Ekanem A, Igenegbale G, Odigie G, Okonofua G, Enigbe R, Oyakhilome J, Yerumoh EO, Odia I, Aire C, Okonofua M, Atafo R, Tobin E, Asogun D, Akpede N, Okokhere PO, Rafiu MO, Iraoyah KO, Iruolagbe CO, Akhideno P, Erameh C, Akpede G, Isibor E, Naidoo D, Hewson R, Hiscox JA, Vipond R, Carroll MW, Ihekweazu C, Formenty P, Okogbenin S, Ogbaini-Emovon E, Günther S, Duraffour S
- Science. 2019 Jan 4;363(6422):74-77. doi: 10.1126/science.aau9343
2018
T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans
- Speranza E, Ruibal P, Port JR, Feng F, Burkhardt L, Grundhoff A, Günther S, Oestereich L, Hiscox JA, Connor JH, Muñoz-Fontela C
- J Infect Dis. 2018 Nov 22;218(suppl_5):S508-S518. doi: 10.1093/infdis/jiy352
Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease
- Kerber R, Krumkamp R, Korva M, Rieger T, Wurr S, Duraffour S, Oestereich L, Gabriel M, Sissoko D, Anglaret X, Malvy D, May J, Županc TA, Muñoz-Fontela C, Günther S
- J Infect Dis. 2018 Nov 22;218(suppl_5):S496-S503. doi: 10.1093/infdis/jiy429
Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses
- Amanat F, Duehr J, Oestereich L, Hastie KM, Ollmann Saphire E, Krammer F
- mSphere. 2018 May 02; 3(3):e00189-18. doi: 10.1128/msphere.00189-18
2017
Erratum for Madelain et al., "Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses"
- Madelain V, Guedj J, Mentré F, Nguyen THT, Jacquot F, Oestereich L, Kadota T, Yamada K, Taburet AM, de Lamballerie X, Raoul H
- Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e02093-17. doi: 10.1128/AAC.02093-17
Determining Ribavirin's mechanism of action against Lassa virus infection
- Carrillo-Bustamante P, Nguyen THT, Oestereich L, Günther S, Guedj J, Graw F
- Sci Rep. 2017 Sep 15;7(1):11693. doi: 10.1038/s41598-017-10198-0
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model
- Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F
- J Virol. 2017 Jul 27;91(16). pii: e00652-17. doi: 10.1128/JVI.00652-17
Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections
- Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C
- PLoS Negl Trop Dis. 2017 May 30;11(5):e0005645. doi: 10.1371/journal.pntd.0005645
Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination
- Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C
- Sci Rep. 2017 Mar 3:7:43776. doi: 10.1038/srep43776
Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study
- Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, Colin G, Rieger T, Oestereich L, Pályi B, Wurr S, Guedj J, Nguyen THT, Eggo RM, Watson CH, Edmunds WJ, Bore JA, Koundouno FR, Cabeza-Cabrerizo M, Carter LL, Kafetzopoulou LE, Kuisma E, Michel J, Patrono LV, Rickett NY, Singethan K, Rudolf M, Lander A, Pallasch E, Bockholt S, Rodríguez E, Di Caro A, Wölfel R, Gabriel M, Gurry C, Formenty P, Keïta S, Malvy D, Carroll MW, Anglaret X, Günther S
- Lancet Glob Health. 2017 Jan;5(1):e80-e88. doi: 10.1016/S2214-109X(16)30243-1
2016
Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses
- Madelain V, Guedj J, Mentré F, Nguyen TH, Jacquot F, Oestereich L, Kadota T, Yamada K, Taburet AM, de Lamballerie X, Raoul H
- Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01305-16. doi: 10.1128/AAC.01305-16
Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes
- Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C
- J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280. doi: 10.1093/infdis/jiw260
Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015
- Kerber R, Krumkamp R, Diallo B, Jaeger A, Rudolf M, Lanini S, Bore JA, Koundouno FR, Becker-Ziaja B, Fleischmann E, Stoecker K, Meschi S, Mély S, Newman EN, Carletti F, Portmann J, Korva M, Wolff S, Molkenthin P, Kis Z, Kelterbaum A, Bocquin A, Strecker T, Fizet A, Castilletti C, Schudt G, Ottowell L, Kurth A, Atkinson B, Badusche M, Cannas A, Pallasch E, Bosworth A, Yue C, Pályi B, Ellerbrok H, Kohl C, Oestereich L, Logue CH, Lüdtke A, Richter M, Ngabo D, Borremans B, Becker D, Gryseels S, Abdellati S, Vermoesen T, Kuisma E, Kraus A, Liedigk B, Maes P, Thom R, Duraffour S, Diederich S, Hinzmann J, Afrough B, Repits J, Mertens M, Vitoriano I, Bah A, Sachse A, Boettcher JP, Wurr S, Bockholt S, Nitsche A, Županc TA, Strasser M, Ippolito G, Becker S, Raoul H, Carroll MW, De Clerck H, Van Herp M, Sprecher A, Koivogui L, Magassouba N, Keïta S, Drury P, Gurry C, Formenty P, May J, Gabriel M, Wölfel R, Günther S, Di Caro A
- J Infect Dis. 2016 October 04; 214(suppl 3):S250-S257. doi:10.1093/infdis/jiw269
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever
- Oestereich L, Lüdtke A, Ruibal P, Pallasch E, Kerber R, Rieger T, Wurr S, Bockholt S, Pérez-Girón JV, Krasemann S, Günther S, Muñoz-Fontela C
- PLoS Pathog. 2016 May 18;12(5):e1005656. doi: 10.1371/journal.ppat.1005656
Unique human immune signature of Ebola virus disease in Guinea
- Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C
- Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949
Development of an antibody capture ELISA using inactivated Ebola Zaire Makona virus
- Krähling V, Becker D, Rohde C, Eickmann M, Eroğlu Y, Herwig A, Kerber R, Kowalski K, Vergara-Alert J, Becker S; European Mobile Laboratory consortium
- Med Microbiol Immunol. 2016 Apr;205(2):173-83. doi: 10.1007/s00430-015-0438-6
Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever
- Oestereich L, Rieger T, Lüdtke A, Ruibal P, Wurr S, Pallasch E, Bockholt S, Krasemann S, Muñoz-Fontela C, Günther S
- J Infect Dis. 2016 Mar 15;213(6):934-8. doi: 10.1093/infdis/jiv522
2015
Ebola virus dynamics in mice treated with favipiravir
- Madelain V, Oestereich L, Graw F, Nguyen TH, de Lamballerie X, Mentré F, Günther S, Guedj J
- Antiviral Res. 2015 Nov;123:70-7. doi: 10.1016/j.antiviral.2015.08.015
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa
- Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R, Abdellati S, Afrough B, Aiyepada J, Akhilomen P, Asogun D, Atkinson B, Badusche M, Bah A, Bate S, Baumann J, Becker D, Becker-Ziaja B, Bocquin A, Borremans B, Bosworth A, Boettcher JP, Cannas A, Carletti F, Castilletti C, Clark S, Colavita F, Diederich S, Donatus A, Duraffour S, Ehichioya D, Ellerbrok H, Fernandez-Garcia MD, Fizet A, Fleischmann E, Gryseels S, Hermelink A, Hinzmann J, Hopf-Guevara U, Ighodalo Y, Jameson L, Kelterbaum A, Kis Z, Kloth S, Kohl C, Korva M, Kraus A, Kuisma E, Kurth A, Liedigk B, Logue CH, Lüdtke A, Maes P, McCowen J, Mély S, Mertens M, Meschi S, Meyer B, Michel J, Molkenthin P, Muñoz-Fontela C, Muth D, Newman EN, Ngabo D, Oestereich L, Okosun J, Olokor T, Omiunu R, Omomoh E, Pallasch E, Pályi B, Portmann J, Pottage T, Pratt C, Priesnitz S, Quartu S, Rappe J, Repits J, Richter M, Rudolf M, Sachse A, Schmidt KM, Schudt G, Strecker T, Thom R, Thomas S, Tobin E, Tolley H, Trautner J, Vermoesen T, Vitoriano I, Wagner M, Wolff S, Yue C, Capobianchi MR, Kretschmer B, Hall Y, Kenny JG, Rickett NY, Dudas G, Coltart CE, Kerber R, Steer D, Wright C, Senyah F, Keita S, Drury P, Diallo B, de Clerck H, Van Herp M, Sprecher A, Traore A, Diakite M, Konde MK, Koivogui L, Magassouba N, Avšič-Županc T, Nitsche A, Strasser M, Ippolito G, Becker S, Stoecker K, Gabriel M, Raoul H, Di Caro A, Wölfel R, Formenty P, Günther S
- Nature. 2015 Aug 6;524(7563):97-101. doi: 10.1038/nature14594
Ebola virus disease in mice with transplanted human hematopoietic stem cells
- Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C
- J Virol. 2015 Apr;89(8):4700-4. doi: 10.1128/JVI.03546-14
Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications
- Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, Oestereich L, Cadar D, Muñoz-Fontela C, Bartoloni A, Schmidt-Chanasit J
- J Clin Virol. 2015 Feb;63:32-5. doi: 10.1016/j.jcv.2014.12.005
Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses
- Gryseels S, Rieger T, Oestereich L, Cuypers B, Borremans B, Makundi R, Leirs H, Günther S, Goüy de Bellocq J
- Virology. 2015 Feb;476:249-256. doi: 10.1016/j.virol.2014.12.011
2014
Emergence of Zaire Ebola virus disease in Guinea
- Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, Soropogui B, Sow MS, Keïta S, De Clerck H, Tiffany A, Dominguez G, Loua M, Traoré A, Kolié M, Malano ER, Heleze E, Bocquin A, Mély S, Raoul H, Caro V, Cadar D, Gabriel M, Pahlmann M, Tappe D, Schmidt-Chanasit J, Impouma B, Diallo AK, Formenty P, Van Herp M, Günther S
- N Engl J Med. 2014 Oct 9;371(15):1418-25. doi: 10.1056/NEJMoa1404505
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
- Oestereich L, Lüdtke A, Wurr S, Rieger T, Muñoz-Fontela C, Günther S
- Antiviral Res. 2014 May;105:17-21. doi: 10.1016/j.antiviral.2014.02.014
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever
- Oestereich L, Rieger T, Neumann M, Bernreuther C, Lehmann M, Krasemann S, Wurr S, Emmerich P, de Lamballerie X, Ölschläger S, Günther S
- PLoS Negl Trop Dis. 2014 May 1;8(5):e2804. doi: 10.1371/journal.pntd.0002804
2010
Entry of bunyaviruses into mammalian cells
- Lozach PY, Mancini R, Bitto D, Meier R, Oestereich L, Overby AK, Pettersson RF, Helenius A
- Cell Host Microbe. 2010 Jun 25;7(6):488-99. doi: 10.1016/j.chom.2010.05.007
